前列腺癌在东亚——十年来的发展现状.pdfVIP

AsianJournalofAndrology 2015 17。48—57 @ 2015AJA SIMM ＆SJTU Allrightsreserved 1008—682X wwwasiaandrocom；wwwajandrologycom OpenAccess INVITED REVIEW ProstatecancerinEastAsia．evolvingtrendoverthe lastdecade YaoZhu，，Hong：KaiWang，，Yuan-YuanQu ，Ding—WeiYe Prostatecancerisnow becominganemerginghealthpriorityinEastAsia．MostofourcurrentknowledgeonProstatecancerhas beengeneratedfrom studiesconducted inWestern population；however,thereisconsiderableheterogeneityofProstatecancer betweenEastandWest．Inthisarticle，wereviewedepidemiologictrends，riskfactors，diseasecharacteristicsandmanagement ofProstatecancerinEastAsianpopulationovertheIastdecade．Growingevidencefrom EastAsiasuggestsanimportantroleof geneticandenvironmentaIriskfactorsinteractionsinthecarcinogenesisofProstatecancer．Exposuretowesternizeddietandlire styleandimprovementinhealthcareincombinationcontributesubstantiallytotheincreasingepidemicinthisregion．Diagnostic andtreatmentguidelinesinEastAsiaareIargelybasedonWesternknowledge．Althoughthereisaremarkableimprovementinthe outcomeoverthelastdecade．ampleevidencesuggestsaninneglectabledi仟erenceindiagnosticaccuracy,treatmentefficacyand adverseeventsbetweendi什erentpopulations。Theknowledgefr0mwesterncountriesshouldbecalibratedintheAsiansettingto provideabetterrace—basedtreatmentapproach．1nthisreview．weintendtoreveaItheevolvingtrendofProstatecancerinthelast decade．inordertogainevidencetoimproveProstatecancerpreventionandcontrolinEastAsia． AsianJourna／ofAndrology 2015 17，48-57：doi：10．4103／1008—682X．132780；publishedonIine：15JulY2014 Keywords：Asians；diagnosis；epidemiology；genetics；prostatecancer；treatmentoutcome INTRODUCTl0N 8．2／100000 ．Japanaccountfor47％，followedbyChina 41％ and Inthelastdecade，EastAsiahasundergonetremendouseconomic Korean 8％ ．Incidencerates IRs variedbyalmost10一ofldacross growth andcultureglobalization,whichresultsin increasinglife thisregion，rangingfrom estimatesof2．56／100000inruralChinaup expectancy,changingindietarypatternandw，esternizedlifest