脉麻醉用于人流术的效果.docVIP

氯诺昔康复合异丙酚静脉麻醉用于人流术的效果 邱爱军 史永胜 刘高望 刘友刚（南方医科大学南方医院麻醉科疼痛诊疗中心，广州 510515） 摘要 目的：评价氯诺昔康复合异丙酚静脉麻醉用于人流术的临床效果及安全性。方法：60例门诊行人流术的早孕妇，随机分为氯诺昔康组（L组，n=30）和芬太尼组(F组，n=30)，L组氯诺昔康16mg、F组芬太尼1μg?kg-1静脉注射后2min，二组均复合异丙酚静脉麻醉。观察平均动脉压（MAP）、心率（HR）、脉搏氧饱和度（SpO2）、意识消失及恢复时间、离院时间、异丙酚总量及不良反应。结果：用药后2min，MAP、SpO2二组均明显低于用药前(P0.01)；该时点SpO2 F组明显低于L组(P0.01)。意识消失时间F组早于L组（P=0.032）；二组意识恢复时间（P=0.427），异丙酚总量（P=0.134），组间比较差异均无显著性。离院时间L组明显早于F组（P0.01）。清醒后眩晕L组明显少于F组（P0.01）。结论：氯诺昔康或芬太尼复合异丙酚静脉麻醉用于人流术镇痛效果相似，但前者呼吸抑制及不良反应轻，有利于病人早期离院。 关键词 氯诺昔康 芬太尼 异丙酚 麻醉 静脉内 人工流产 Effects of lornoxicam combining with propofol for anesthesia in therapeutic abortion QIU Ai-jun SHI Yong-sheng LIU Gao-wang LIU You-gang (Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515) Abstact Objective: To evaluate the clinical efficacy and safety of anesthesia with intravenous lornoxicam combined with propofol for therapeutic abortion. Methods: Sixty the early stage of pregnancy women (ASAⅠ~Ⅱ) were scheduled for therapeutic abortion, which were randomly divided into two groups to receive anesthesia with either intravenous lornoxicam 16mg (group L,n=30) or fentanyl 1μg?kg-1 (group F,n=30), and both groups were all combined with propofol. The mean arterial blood pressure(MAP), heart rate(HR), oxygen saturation(SpO2), consciousness loss time，recovery time and discharged from hospital time, dosage of propofol and adverse effects were recorded. Results: At 2 min after anesthesia induction, MAP and SpO2 were divided into two groups respectively. Two groups were significant lower than before anesthesia induction(P0.01), group F of SpO2 was lower than group L(P0.01). Group F of consciousness loss time was earlier than group L(P=0.032). There was no significant difference of consciousness recovery time between group L and F( P=0.427), but group L of discharged from hospital time was earlier than group F(P0.01), and group L of giddiness after consciousness recovery was less than groupF(P0.01). There was no significant