红豆杉多糖对犬心肌缺血_再灌注损伤左室舒张功能及心肌梗死质量的影响.pdfVIP

∀ 370∀ J ChinM icrocircOct. 2009, Vo.l 13, No. 5 : 2009) ∀ ∀ 红豆杉多糖对犬心肌缺血 再灌注损伤 左室舒张功能及心肌梗死质量的影响 朱天民,朱慧民, 李 辉 #∃ (MIRI) , 30 , 6, 7 d,MIRI BIOPAC 53060min in 120 min 9 (LVEDP)(LVdp/dtmax); TTC 5m in 30min 3060m inLVEDP( P 0. 05), 10m inLVEDP (P 0. 05); 3060min,10306090120min LVdp/dtmax (P 0. 05); LVdp/dtmax 60min, 3060120m in (P 0. 05); LVdp/dtmax 90120m in( P 0. 05) (P 0. 05) MIRI #∃ ; ;; + : R542. 2 2 : B The Prelim inary Study of the Impact of on LeftV entricular D iastolic Function and the D egree of M yocardial Infarction TaxusPolysaccharide inM IRIM odel of Beagle Dogs ZH U Tianm in, LI H u ,i A cup uncture college of Cheng du T CM University, Chengdu 610075; ZH U H ui m in, Tai hou cen tralH osp ita,l China #A stract∃ O jective To observe the influence of taxus polysaccharide on left ventricular diastolic function and the degree ofmyocardial infarction inMIRImodel of beagle dogs to provide expermi ental evidence for clinical application. M ethods 30 beagle dogs were random ly divided into sham operation group, model group, lowdosetaxolpolysaccharidegroup, highdose taxolpolysaccharide group and carvedilolgroup, 6 in each group, andMIRImodelwas established after7 days adm inistration. UseBIOPAC 16 path physiological recorder Biology SignalAnalysisobservateand record left ventricular enddiastolicpressure(LVEDP), themax rateof rise of left ventricular pressure(LVdp/dtmax) at different tmi es: 5m in, 30m in and 60 min ischem ia, 10m in, 30 m in, 60min, 90min and 120m in perfusion; TTC dyeingwas used todeterm ine the degreeofmyocardial infarc tion occupy percentage ofwhole heart or left ventricularmyocardium. R esults Comparedw ith the sham opera tion group, LVE