中药提取物微囊化防潮技术和其机理研究.pdfVIP

中药提取物微囊化防潮技术及其机理研究 冯 怡，刘 怡，徐德生 （上海中医药大学，上海 201203） 摘要：目的考察喷雾干燥工艺对鞣质微囊防潮效果的影响，并研究了造成影响 的机理。方法 喷雾干燥制成的鞣质微囊置于一定温湿环境中12 h，绘制吸湿曲 线以研究进风温度、供液速度、雾化气流速与微囊防潮效果间的规律；并从微囊 溶剂残留量、成膜过程膜收缩行为和微囊粒径 3 个方面研究造成这些规律的机 理。结果 微囊防潮效果随着进风温度的提高、供液速度的降低、雾化气流速的 降低而增强；反之则减弱。造成这种影响是由于成囊过程中囊壁致密程度、微囊 中溶剂残留以及微囊粒径不同而造成的。结论 喷雾干燥制备微囊不同工艺参数 制得的微囊的物理状态不同，其防潮效果也不同。 关键词：喷雾干燥；微囊化；防潮效果；机理；溶剂残留量；膜收缩行为；粒径 Influencing Factors on Dampproof Effect of Microcapsules and Study on Mechanism Feng Yi, Liu Yi, Xu De-sheng (Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China) Abstract: Objective The influence of spray drying technology on the damp proof effect of microcapsules and the mechanism were studied. Method The microcapsules prepared with different spray drying parameters have been put in certain surroundings for 12 hours, then the hygroscopic curves were gotten; the mechanism was studied from the following aspects: solvent residue, film’s shrink and particle size. Result The damp proof effect enhanced with the increase of inlet air temperature and the decrease of flow rate and air pressure. The properties of the wall, the solvent residue and particle size can influence the damp proof effect of the microcapsules. Conclusion The physical properties of microcapsules are different because of the different spray drying parameters, which lead to different dampproof effect of microcapsules. Key words: spray drying; microcapsulation; dampproof effect; mechanism; solvent residue; film’s shrink; particle size 作者简介：冯怡，女，教授，博士生导师，研究方向：中药制剂关键技术。 Tel: (021Fax: (021E-mail: fyi@ 在药品生产过程中，中药提取物较强的吸湿性是导致制剂成型困 难最主要的因素[1，2，3] ，因此应在成型前适当降低提取物的吸湿性以 保证生产过程的顺利进行。微囊化是近几十年来应用于药物的新工