FusapyroneandDeoxyfusapyrone的分离鉴定.pdfVIP

J. Antibiot. 59(11): 704–709, 2006 THE JOURNAL OF ORIGINAL ARTICLE ANTIBIOTICS Isolation and Structure Elucidation of Neofusapyrone from a Marine-derived Fusarium species, and Structural Revision of Fusapyrone and Deoxyfusapyrone Fuminori Hiramatsu, Takeshi Miyajima, Tetsuya Murayama, Koetsu Takahashi, Takuya Koseki, Yoshihito Shiono Received: August 18, 2006 / Accepted: November 1, 2006 © Japan Antibiotics Research Association Abstract Three polyketides containing a pyrone ring, antimicrobial activity against Aspergillus clavatus . neofusapyrone, fusapyrone, and deoxyfusapyrone, were Bioassay-guided fractionation of the extract resulted in the isolated from the marine-derived fungus Fusarium sp. FH- isolation of neofusapyrone (1), fusapyrone (2), and 146. Their structures were determined by extensive 1D- and deoxyfusapyrone (3) (Fig. 1). Here, we describe the 2D-NMR and MS spectral analyses. Fusapyrone and isolation, structure elucidation, and biological activities of deoxyfusapyrone were originally reported as a -pyrone the three related pyrone derivatives along with the revision derivatives; however, the revised structures indicate that of the structures of the previously reported antifungal they are g -pyrone derivatives. These three compounds mycotoxins, namely, fusapyrone and deoxyfusapyrone, exhibited antimicrobial activities. from Fusarium semitectum [4]. Fusarium sp. (section Liseola) FH-146 was cultivated on Keywor