缬沙坦对慢性心房快速起搏犬血小板和内皮功能的影响.pdfVIP

! 102! CH INESE JOURN L OF PR CT IC L INTEN L MEDICINE January 2006 Vol26 No2 李 悦, 李为民, 薛竟宜, 韩 薇, 盛 力, 杨树森, 谷宏越 1005- 2194 (2006) 02- 0102- 03 R5 探讨缬沙坦对慢性心房快速起搏 发心房颤动 (房颤) 犬血小板和内皮功能的影响 2001- 09~ 2003- 06对哈尔滨医科大学 14只犬植入实验用心房固定频率型高频起搏器 ( 400/m in) 心房快 速起搏 6周, 建立房颤犬模型, 随机分为对照组和缬沙坦组缬沙坦组犬起搏前 1周开始服用缬沙坦 - 1 - 1 ( 30mg! kg ! d ), 直至起搏结束起搏前后采静脉血测定二磷酸腺苷肾上腺素胶原花生四烯酸 导的犬血小板最大聚集率以及血浆血管性血友病因子 ( vWF)内皮素 1 ( ET - 1) 和血管紧张素∀ ( ng∀ ) 的变化 ( 1) 起搏 6周后, 对照组和缬沙坦组犬血浆 ng∀水平均明显增高, 提示肾素- 血管紧张素 系统激活( 2) 长期心房快速起搏使对照组犬二磷酸腺苷肾上腺素胶原和花生四烯酸 导的血小板最大 聚集率较起搏前明显增加, 缬沙坦能够部分抑制起搏引起的血小板激活( 3) 快速起搏使犬血浆 vWF和 ET - 1水平明显升高, 提示内皮功能受损, 缬沙坦能够改善内皮功能, 降低房颤犬血浆 vW F和 ET- 1水平 缬沙坦能够防治心房快速起搏引起的血小板聚集和内皮功能受损 血管紧张素; 内皮素; 血小板; 缬沙坦; 犬 E ffec t of valsartan on p late let and endoth elial func tion in chron ic rap id atrial pacin g dogs L i Yue, L i We im in, X ue J ingy i, et alD epartm ent of Card io logy, the F irst C linical College, H arbin M ed ical Uni ersity, H arb in 150001, China A bstrac t O bject ive To investigate the effects ofvalsartan on platelet and endothelial function in atrial fibrillation dogs induced by chronic rapid atrial pacingM ethods From Sep2001 to Jun2003, 14 dogs paced at 400 bpm in the right atrium for 6 weekswere random ly divided into controlgroup and valsartan groupThe dogs in valsartan group received val - 1 - 1 sartan ( 30 mg! kg ! d ) 1 week before rapid atrial pacing until pacing stopThe plasma von W illebrand factor ( vWF), endothelin- 1 ( ET- 1) , angiotensin ∀ ( ng∀ ) levels and blood platelet aggregation ratewere measured before and after rapid atrialpacingResu lts ( 1) P lasma ng∀ levelelevated significantly in both groups, indicating activation of renin- angiotensin system ( 2) Themaxmi am platelet aggregation rates