巴曲酶对深_度烫伤创面微循环血流变化及愈合的影响_胡骁骅.pdfVIP

2000 8 16 4 Chin J Burns, Au ust 2000 Vol . 16,No. 4 # 241 # ## Ò 胡骁骅 孙永华 陈忠 覃凤均 = Wistar 20 , , 4 cm @ 4 cm Ò0. 5246122472 h ; 1418 d ; 30 d 272 h ; , , , , = ; Ò; ; ; The effects of batroxobin on the healin of and the microcirculatory blood flow volume in deep partial thickness burn wounds in rats HU Xiaohua, SUN Yon hua, CHEN Zhon , et al. Department of Burns, Jishuitan Hospital. Beijin 100035, P. R. China = Abstract Objective To investi ate the effects of batroxobin on the healin of and the microcirculatory blood flow in deep partial thickness burn wounds in rats. Methods Wistar rat inflicted by 4 cm @ 4 cm deep partial thickness scaldin on the back was taken as the model. Twenty male rats were randomly divided into scald- in burn roup and batroxobin treatment roup. Cutaneous blood flow volume was measured before and at 0. 5, 2, 4, 6, 12, 24 and 72 postburn hours( PBH) . Scaldin and residual burn wound areas were measured immediately and on the 14th and 18th postburn days( PBD) . The rats were sacrificed on 30th PBD and the cutaneous samples were harvested for hair follicle countin and histolo ical examination with LM. Results The cutaneous blood flow volume of rats in sin le burn roup decreased pro ressively durin 2- 72 PBHs. But in batroxobin treatin roup, cutaneous blood flow volume improved evidently and the wound healin accelerated obviously with increased cutaneous appenda e formation. Conclusion Batroxobin mi ht restore the blood circulation of stasis band of burn wound, so as to accelerate wound healin and to improve the quality of healed skin. = Key words Batroxobin; Deep partial thickness burn; Burn wound; Microcirculation of stasis band; Healin [ 1- 4] ,