辛伐他汀对短暂性脑缺血发作患者颈动脉粥样硬化斑块和血脂影响的研究.pdfVIP

2008, 14( 4) Journal of H ainanM ed ical Co llege 349 1 2 2 2 2 2 , , , , , ( 1., 518118; 2. , 524000 ) [] 目的:观察辛伐他汀对短暂性脑缺血发作(T lA)患者颈动脉粥样硬化斑块和血脂水平的 响及 临床疗效方法: 66例有颈动脉粥样硬化斑块的 TIA 患者随机分为辛伐他汀组(简称他汀组)和对照 组:他汀组口服辛伐他汀和阿斯匹林 6 个月, 对照组仅口服阿斯匹林, 治疗前后进行颈动脉超声检查, 观察颈动脉内中膜厚度( IMT)动脉粥样硬化斑块面积, 检测血脂水平, 比较治疗 6 个月内两组患者脑 血管事件的发生率结果: 治疗后他汀组血胆固醇低密度脂蛋白甘油三酯水平比治疗前明显下降, 高 密度脂蛋白水平明显升高(均P 0. 01);颈动脉 IMT 变薄及斑块面积减少, 与对照组比较差异均有显 著性(P 0. 05); 他汀组脑血管事件的发生率为 9. 09%, 对照组为 21. 21%, 两组间差异无显著性(P 005) 结论: 辛伐他汀不仅有调整血脂的作用, 还具有抗脂质氧化保护血管内皮等多种作用, 并能消 除或稳定T IA 患者的颈动脉粥样硬化斑 [] 脑缺血, 暂时性; 动脉粥样硬化;颈动脉血栓形成; 胆固醇; 甘油三酯类; 脂蛋白类; 辛伐他汀 [] R743. 31 [] A [] 2008) Effects o f smi vasta tin on a therosc lero t ic p laque o f caro t id and b lood lip id leve l o f pa t ients w ith trans ient ischem ic a ttack 1 2 2 2 2 2 CHEN hen , SU D anxia, HU M eirong, WEI Y ier, L IV Jinghai, FU L ijiang ( 1. D ep artment of In ternalM ed icine, P inshan P eop lesH osp ital of Shenzhen C ity Shenzhen 518118, China; 2. Cen tralH osp ital of Guangdong P ro inceAgricu lture Reclam ation, Zhanj iang 524003, China) [ ABSTRACT] O b ec tive: To observe the effects of smi vastatin on atherosclerotic plaque of carotid and blood lipid level of patientswith transient ischem ic attack (T lA) and clinical efficacy. M ethods: Sixtysix cases of pa tients having carotid atherosclerosis and TIA were random ly divided into trial group and control group. T rial group took smi vastatinw ith aspirin orally for six months, the control group only aspirin orally. The ultrasonic exam ination of carotid artery intmi a andmedia thickness ( IMT ), atherosclerosis area and determ ination of blood lipid leve