雷公藤固态生物转化产物减毒增效作用的实验研究.pdfVIP

中草药 Chinese Traditional and Herbal Drugs 41 6 2010 6 92 1 2 1 3 3 3 马伟光, 毕 云 ,黄之镨 ,钱如贵 ,李婵娟 , 浦仕彪 ( 1 , 650500; 2 , 650032; 3 , 650111) : , ; ip ( TW1) , ; (T W2) , , : ; ; ; : R2855 : A :0253- 2670(2010) 06- 0927- 04 More activity and less toxicity of extracts from solid fermented medicinal plant Trip tery g ium wilf ord ii 1 2 1 3 3 3 MA Weiguang , BI Yun , UANG Zhipu , QIAN Rugui , LI Chanjuan , PU Shibiao ( 1Research Center for Biotransformation of Meditational Plants of Yunnan University of Traditional Chinese Medicine, Kunming 650500, China; 2. Kunming Medical College, Kunming 650032, China; 3. Yunnan Institute of M ateria Medica, Kunming 650111, China) Abstract: Objective In order to reduce the toxicity and still maintain the bioactivity of the medicinal plant T rip t er y g ium w i lf ord ii (TW) , thewhole plant biotransfomed methodwas employed. By observing the pharmacological activities and the toxicity of MeO extracts from the root of T . w i lf or d i i that were biotransformed by the fungi A sp erg il l ums spp. and Rh iz op us spp. , the best biotransformed fungi strain has been selected based on the experimental data. Methods Applying the models of acute and chronic in flammation, theweight of immune organ and cell immunity were used to study the pharmacological activi ties, and ip injection to observethe