瞬时受体电位通道C亚族参与高血压心室肥厚机制研究的新进展.pdfVIP

Review 308 Ca2+ C Transient receptor potential channels, TRPCCa2+ TRPC TRPC calcineurin, CaN)T nuclear factor of activated T cells, NFAT TRPC TRPC Ca2+ New progress of the study on the effect and mechanism of TRPC channels in the development of hypertension induced ventricular hypertrophy The development and reversal of myocardial hypertrophy is always as a hot spot in the study of cardiovascular disease. Tradition- Abstract ally, Ca2+ overload is seen as the foundation of myocardial hypertrophy. Recent years, related studies found transient receptor potential channels (TRPC) may play a certain role in the development of myocardial hypertrophy through adjusting the alteration of intracellular Ca2+ . Besides, new evidences have demonstrated the regulating effect of TRPC channels in ventricular hypertrophy mainly achieves through the activation and self regulation of TRPC channels, the effect of microdomain in the heart and the coordination with signaling effectors such as calcineurin and NFAT (nuclear factor of activated T cells). TRPC channels may become a new pharmacological target on the inhibition and reversal of ventricular hypertrophy. Key wordsTRPC channels; Ventricular hypertrophy; Ca2+ ; Signaling pathway CaN-NFAT TRPC 2 1 0 2 r e b o t c O 5 . o N TRP 2 Ca2+ 1 e m 28 TRP 7 u l o