肠易激综合征患者肠黏膜超微结构改变的电镜观察.pdfVIP

293 ( ) Vol.29 o. 3 2 0 0 8 6 Journal of Xi an Jiaotong University(Medical Sciences) Jun. 2008 肠易激综合征患者肠黏膜超微结构改变的电镜观察 1 1 2 1 1 孔武明, 龚 均 , 陈明霞, 董 蕾 , 秦 斌 ( 1. , 710004; 2. , 710076) :目的 ( IBS) ,IBS 方法 IBS 10 , 结果 , IBS ; ,4 IBS, ,结论 , IBS :; ; :R574.4 :A : 2008 Ultrastructural changesinthe intestinal mucosaof patientswithirritablebowelsyndrome 1 1 2 1 1 Kong Wuming , Gong Jun , Chen Mingxia , Dong Lei , Qin Bin ( 1. Department of Gastroenterology, the Second Affiliated Hospital, Medical School of Xian Jiaotong University, Xian 710004; 2. Center of Electron Microscopy, Medical School of Xian Jiaotong University, Xian 710076, China) ABSTRACT: Obj ective To study the ultrastructural changes including chalice cell, plasma cell neuroendocrine cell and mast cell in the intestinal mucosa of patients with irritable bowel syndrome ( IBS) , and elucidate their possible effects on the pathogenesis of IBS. Methods Of 10 normal controls, 10 constipation predominant IBS ( IBSC) and 10 diarrhea predominant IBS( IBSD) , biopsies were taken from the terminal ileum and ascending colon. Under electron microscope, we observed the ultrastructural changes including chalice cell, plasma cell, neuroendocrine cell and mast cell of the intestinal mucosa. Results In both colonic mucosa and small intestinal mucosa of patients with IBS, mucocysts and fused mucocysts were obviously increased in the chalice cells, of which the secretion was abundant. The neuroendocrine cells and mast cells were also