小分子伯胺催化异噁唑有氧还原开环反应.pdfVIP

ChineseJournalofCatalysis36(2015)204-208 催化学报 2015年 g36卷 第2期 1www．chxb．cn avaiIabIe atwww．scierlcedirect．com ：scienceDirect journaIhomepage：www．eIseVier．com ／Iocate／chnjc Article —Siimpl’epriimarvam linecatal’yzed’aerob’iicred●uctiIveri一nR-c0leavaReof^ isoxazolem otif ZhongkuiZhao ，RenzhiLi，YuLi，GuiruW ang StateKeyLaboratoryofFineChemicals,DepartmentofCotelysisChemistryandEngineering,SchoolofChemicalEngineering,DalianUniversityof Technology,Dalian116024Liaoning,China A R T IC L E IN F 0 A B S T R A C T Articlehistory： A clean and highly efficient catalytic aerobic reductive ring-·cleavage of 3-methylan- Received25June2014 thra[1，2一c]isoxazole-6，11一dioneto1-amino一2-acetylanthraquinonewasperformedusingsimple Accepted18July2014 organicaminesasorganocatalystsandwaterasagreenreactionmedium ．Thismethodprovidesa Published20February2015 new cleantransformationofisoxazole—-containingcompoundstothecorrespondingortha-·amino ketones．Thecatalyticperformanceofvariousorganicamineswascarefullyscreened，andsimple organicprimaryam ineswerefoundtObeprom isingpracticalcatalystswithoutstandingcatalytic Keywords： performance．1sopropylamine as the organocatalyst gave 97．2％ conversion of 3-methylan— 0rganOcata1ysis Simpleprimaryamine thra[1，2-c]isoxazole一6，11-diane，with97．2％ selectivityto1-amino一2-acetylanthraquinone，inthe presenceofoxygenonly,using1equiv．ofhydrazinehydrateatroom temperaturefor3h．Apossi— Aerobicreductiveringcleavage