p63、P504S、Ki67在乳腺良恶性疾病中的表达及意义.pdfVIP

维普资讯 · 论 著 · 2007年11月第45卷第2l期 p63、P504S、Ki67在乳腺良恶性疾病中的表达及意义 侯苋芬 许东哲2 (1．福建医科大学教学医院宁德市闽东医院肿瘤科 ，福建福安 355000；2．延边大学附属医院普外三科 ，吉林延吉 133000) [j齑要】目的 探讨p63、P504S、Ki67在乳腺良恶性疾病中的表达及临床意义。方法 用免疫组化法研究54例乳腺良恶性疾 病中p63、P504S及Ki67的表达。结果 在乳腺良性病变组中p63阳性率是 100％，PStrts和Ki67均阴性；在浸润性导管癌及 浸润性小叶癌中O63均呈阴性；在良恶性病变组之间，Ki67阳性表达率有显著性差异(P0．01)；导管癌 P504S表达阳性 ， 而小叶癌P504S则表达阴性。结论 p63蛋白表达强度在 良性肿瘤较强，恶性肿瘤最弱。P504S的染色有助于小叶癌与导管 癌的鉴别诊断。Ki67的检测可作为鉴别乳腺 良恶性疾病的一种辅助诊断方法。 关【键词】乳腺肿瘤；免疫组化；O63；P504S；Ki67 [中图分类号】R737．9 [文献标识码】A [文章编号11673—9701(2007)21—24-02 The Expression and Significna ce of p63，P504S na d Ki67 in Breast Benign na d Maling na tLesions HOU Pengfen XU Dong~ ex 1．DepartmentofOneology，FujianEastHospital,TeachingHospitalofVujianMedicalUinversity，Fujian355000；2．DepartmentofGeneral Surgery，TheAffiliatde HospitalofYanbianUniversity，Jilin 133000 A【bstractlObjectiveTostudytheexpressionandclinicalsignificnaceofp63．P5O4SnadKi67inbreastbening nadmalingnat lesions．Methods The expression of p63，P504S nad Ki67 in 54 cases of the bening nad malingnat lesions examined hv immunohistochemistry methods．Results Th e positive rate of p63 was expressde in bening breastlesionsat 100％ while P504s nad Ki67 remainde negative，appeared negative in invasiveduetalcarcinomana d invasive lobularcarcinoma． Between bening breastlesions nadcarcinomatissues，htepositiveof Ki67hadobviousdistinctiveness(P0．01)．P504Sof breastductal cracinomaremainedpositive． P504S of breastlobulra carcinoma lobularcracnioma of hte breastWas expressde as negative．Conclusion Th e expression strength p63iShigherin bening tumors nad lowestni malingna tutmors．P504Sfacilitates tl1eclearident访cation of lobularna d ductcarcinoma． 1(i67 detection Cna be servea as na nacillary