不同相对分子量透明质酸功能应用研究.pdfVIP

不同相对分子量透明质酸功能及应用的研究 潘艺茗 薛静 黄岳山 吴效明 （华南理工大学生物科学与工程学院，广东广州 510006 ） 摘要：透明质酸是一种大分子粘多糖，其生物活性和使用效果具有 Mr 相关性，应根据使用目的的不同， 选择合适的分子量。本文主要综述了，近年来不同相对分子量透明质酸功能及应用的研究进展，其中详细 介绍了高分子量的 HA 具有较好的粘弹性、保湿性、抑制炎性反应、润滑、药物缓释等功能，及在骨关节 炎的治疗、术后防粘连、眼科手术黏弹剂和滴眼液等领域的广泛应用；低分子量HA( LMWHA )和HA 寡 聚糖( o-HA ) ，有抗肿瘤、促进伤口愈合、促进血管生成、免疫调节等作用，且通过对 HA 的降解可获得 LMWHA 和o-HA 。 关键词：透明质酸　分子量 功能 应用 Research on the function and application of different molecular weight hyaluronic acid PAN Yiming, XUE Jing , HUANG Yueshan, WU Xiaoming (Biological Science and Engineering College, South China University of Technology, Guangzhou 510006, Guangdong Province) Abstract ：Hyaluronic acid is a kind of macromolecular mucopolysaccharide, which biological activity and use effect associate with its molecular weight,so we should be depending on the different purpose, select the appropriate molecular weight. This paper reviews the progress on the function and application of different molecular weight hyaluronic acid in recent years,detailing the high molecular weight HA (HMWHA) has been widely applied in the fields of treatment of osteoarthritis, postoperative anti-adhesion, viscoelastic agent ophthalmic surgery and eye drops, because of its characteristics in good viscoelasticity, water-holding, suppress inflammation response, lubricate, drugs slow release and so on; low molecular weight HA (LMWHA) and HA oligosaccharides (o-HA) have the function of anti-tumor, promoting wound healing, promoting angiogenesis, immune regulation and so on ,and by the degradation of HA can get the available LMWHA and o-HA. Keywords: hyaluronic acid molecular weight function application 透明质酸(Hyaluronic acid,HA)是一种在所有脊椎动物器官和血液中均可发现，并在软结 缔组织的细胞外基质中广泛分布的酸性粘多糖。透明质酸具有高度粘弹性、可塑性、超强 的持水性、渗透性和良好的生物易