高血压急症患者静脉应用地尔硫卓和硝酸甘油疗效观察.pdfVIP

高血压急症患者静脉应用地尔硫卓和硝酸甘油疗效观察 陈瑜越 江慧琳 林珮仪 赵贤武 摘 要 目的 比较静脉注射地尔硫卓和硝酸甘油治疗高血压急症患者的疗效。方法 37 例舒张压≥110mmHg 和（或）收缩压≥180mmHg 的高血压急症患者随机分为地尔硫卓组 （n=18）和硝酸甘油组（n=19）。地尔硫卓和硝酸甘油的用法分别为50mg 和 20mg 静脉 注射。记录用药后 5、10、15、30 和 60min 时的患者血压和心率。结果 和用药前比较， 两种药物均能显著降低高血压急症患者的血压（P0.01 ），但硝酸甘油对降低舒张压起效稍 慢，而对收缩压降压效果更明显。在降低血压的同时，两种药物亦使心率有所降低，但两组 间的减慢心率作用比较无显著差异，两组均未见低血压和心动过缓者。治疗 60min 后，两 组的治疗有效率分别为 94.1%和 100% （P0.05 ）。结论 静脉注射地尔硫卓和硝酸甘油治 疗高血压急症均安全有效。 关键词 高血压急症 地尔硫卓 硝酸甘油 静脉注射 Comparison of the Effectiveness of Intravenous Diltiazem and Nitroglycerin in Controlling the Blood Pressure in Patients with Hypertension Emergency Yuyue Chen Huilin Jiang Peiyi Lin Xianwu Zhao Department of Emergency, the second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260 Abstract Objective: To compare the effectiveness of intravenous (IV) diltiazem and nitroglycerin in controlling the blood in patients with hypertension emergency(HE). Methods thirty-seven HE patients with a diastolic blood pressure （DBP）≥110 mmHg and （ or ）systolic blood pressure(SBP)≥180 mmHg were divided into diltiazem group (50mg, IV, n=18) or nitroglycerin group (20mg, IV, n=19). Blood 510260 广东省广州市 广州医学院第二附属医院急诊科 E-mail：xiaoyuerpbe@163.com ；通讯地址：昌岗东路250 号广州医学院第二附属医院 急诊科 pressures and heart rate were measured at 5, 10, 15, 30 and 60 minutes. Results A significant decrease in the blood pressure of HE patients were observed in both treatment groups (P0.01). However, the decrease in DBP was slower in the nitroglycerin group than that in the diltiazem group. While the antihypertensive effect on SBP was significantly higher that in the nitroglycerin group （P0.05 ） Meanwhile, a slight decline in the ventricular rate was observed in both groups. The drop of