30-Year Follow-Up Study in Patients with Lone Atrial Fib.ppt

30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation This study was conducted to: Investigate the potential predictors in patients with intermittent atrial fibrillation who progress to permanent atrial fibrillation. Evaluate the associated comorbidities and their implication in the progression and complications in patients with lone atrial fibrillation in relation to a similar matched population. 71 patients Paroxismal AFib (n=34) Persistent AFib (n=37) Persistent AFib (n=5) - excluded Median age 44?11 yr No SHD/no HTN Mean F-U 30 yr Natural History of Lone Atrial Fibrillation Natural History of Lone AFib (Stroke/TIA) Older age is an independent predictor of progression from paroxysmal to permanent lone atrial fibrillation, as well as an univariate predictor of increased mortality and cardiac mortality rates. Associated comorbidities influence the progression and risk of complications in patients with Atrial Fibrillation. Arshad jahangir, MD; Victor Lee, MBBS; Paul A. Friedman, MD; Jane M. Trusty, RN; David O.Hodge, MS; Stephen L. Kopecky, MD; Douglas L. Packer, MD; Stephen C. Hammil, MD; Win-Kuang Shen, MD; Bernard J. Gersh, MBChB, DPhil. 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation: Objectives 30-Year Follow-Up Study in Patients with Lone Atrial Fibrillation Jahangir , Friedman et al, Circ 2007 Jahangir , Friedman et al, Circ 2007 Cumulative Survival Survival fromdeath (%) Expected Observed P=0.120 Years after diagnosis of AFib CP1173154-1 Cumulative Survival Free ofStroke/TIA Years after diagnosis of AFib Survival free ofstroke/TIA (%) Expected Observed P=0.014 Natural History of Lone AFib (Stroke/TIA) Jahangir , Friedman et al, Circ 2007 Cumulative Survival Survival fromdeath (%) Expected Observed P=0.120 Years after diagnosis of AFib Cumulative Survival Free ofStroke/TIA Survival free ofstroke/TIA (%) Expected Observed P=0.014 71 patients Median age 44?11 yr Paroxysmal AFib No SHD/no HTN Mean F-U 30 yr