Chemical Engineering in the Biotech Industry.ppt

Chemical Engineering in the Biotech Industry D. Davidson Easson Jr., ScD VP Manufacturing Process Development Epic Therapeutics / Baxter Healthcare Biotech / Biopharmaceuticals in MAAn important part of our economy MA is a leader in the biotech industry (8% of world’s new drug pipeline comes from MA companies*) Biotech is a leading industry in MA (280 companies with 30,000 employees*) RD accounts for 40% of the biotech jobs in MA, whereas the Pharma industry average is 15%**, indicating that this is still a developing and growing industry *MassBiotech 2010, BCG MBC 2002 Report **Scott Sarazen, MassDevelopment at MBC 2004 Annual Meeting Biotech / Biopharmaceuticals in MAA young, maturing industry Late stage development and manufacturing require chemical and biochemical engineers for: Product Development Process development Manufacturing Biotech / Biopharmaceuticals in MAShifting from science to engineering Need Thus, there is a growing need in Massachusetts for chemical and biochemical engineers as the biotech industry matures. Solution WPI CHE Dept. should position itself to help fill this need. Where are the future opportunities and challenges in chemical engineering? Functional Areas Formulation Development Process research and development Process scale-up Equipment / Process design Technology transfer Plant design Manufacturing Where are the future opportunities and challenges in chemical engineering? Technology Areas Fermentation Cell culture Enzyme technology Homogenization, centrifugation, precipitation Micro Ultrafiltration Chromatography Drying technologies Aseptic processing Drug Delivery What skill sets will be required? Versed in biochemical processes Integration of biology into Chem. Engineering Training in microbiology and aseptic technique Fundamentals of fermentation, cell culture and bioseparations CAD and Process modeling Experimental Design Basics of Good Manufacturing Practices (GMPs) What skill sets will be required?(continued) E