冷冻浇注法制备羟基磷灰石多孔陶瓷.pdfVIP

J26 冷冻浇注法制备羟基磷灰石多孔陶瓷 张妍， 张斗， 张晓泳， 李志友， 周科朝 (中南大学粉末冶金国家重点实验室，湖南省长沙市 410083) 摘要：近年来关于羟基磷灰石(Hydroxyapatite, HA,Ca (PO ) OH)基多孔陶瓷作为承重、骨替代及骨再生材料应用于生物医学领 5 4 3 域的研究受到广泛关注。本研究采用水基 HA 浆料，通过冷冻浇注工艺制备多孔 HA 陶瓷。利用流变仪对浆料体系的流变性能 进行表征，采用 XRD 和 SEM 等测试手段对烧结样品的物相和微观形貌进行检测，通过 Archimedes 排水法测试样品的孔隙度。 结果表明所得多孔 HA 陶瓷具有单一取向的层状多孔结构,且在冷冻浇注过程中可以通过调节过程参数实现对孔隙率及孔微观 形貌的有效调控，显示了冷冻浇铸工艺在制备骨组织工程用多孔 HA 基陶瓷方面具有较高的潜在应用价值。 关键词：羟基磷灰石；冷冻浇铸；多孔陶瓷；微观结构 Freeze casting of porous hydroxyapatite ceramics ZHANG Yan, ZHANG Dou, ZHANG XiaoYong, LI ZhiYou, ZHOU KeChao (State Key laboratory of Powder Metallurgy, Central South University, Changsha 410083, China) Abstract: In recent years, considerable attention has been given to the research of Hydroxyapatite-based (HA, Ca (PO ) OH) porous ceramics for load bearing, bone substitute, bone regeneration applications. 5 4 3 Freeze casting of aqueous slurry was investigated as a method for preparing HA ceramics with unidirectional lamellar pore structures. The rheologic properties of the slurries were characterized by viscosity measurements. The phase structures, microstructures and porosities of sintered HA samples were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Archimedes method, respectively. These show that the freeze casting route has great potential for the preparation of porous HA ceramic in bone tissue engineering applications. Keywords: Hydroxyapatite, Freeze casting, Porous ceramics, Microstructure 羟基磷灰石(hydroxyapatite, HA)是一种微溶于水的弱碱性磷酸的钙盐，是脊椎动物骨和齿的主要无机成 分[1,2]，羟基磷灰石多孔生物陶瓷具有良好的生物相容性和化学稳定性，其相互连通的孔隙有利于组织液的微 循环和新骨细胞的攀附生长, 并为新生骨提供营养, 促进纤维组织和新生骨的结合和生长, 是一种性能优异 的硬骨组织替代材料