骨质疏松骨折基础和临床研究方法进展.pdfVIP

固匪凼佥鎏岱谢盘查垫!!笙!旦笠!!鲞筮!塑丛』垦!鱼塑至!!!丛!些：丛!里!垫!!：Y!!：!!：盟!：兰 ·综述· 骨质疏松骨折基础和临床研究方法进展 吴博戴如春 【摘要】 骨质疏松是一种常见的代谢性骨病，其最严重的危害在于发生骨折。骨质疏松骨折与 骨量减少和骨组织微结构退行性改变有关。对骨微结构、微损伤的基础研究有助于揭示骨折机制，而 临床运用影像学手段可检测骨结构变化，结合有限元分析可预测骨折危险性。独立于骨结构的代谢 途径标志物及骨折风险评估工具对骨折的早期防治也起了积极作用，关注已骨折患者的生命质量可 降低再骨折风险。这些研究方法将为骨质疏松骨折危险性分析、药效检测等提供新的研究方向和 思路。 【关键词】骨质疏松骨折；微结构；骨转换 ofbasicandclinicalresearchmethodson fractureWU Ru—chun． Development osteoporostic Bo，DAI InstitutionMetabolismand Second South of Endocrinolog)’，TheXiangyaHospital，CentralUniversity，Changsha 41001 1，China author：DAI CorrespondingRu—chun，Email：daimchun@)ahoo．COWl．cn isacommonmetabolicbonediseaseandfractureisitsmostseriousconse． 【Abstract】Osteoporosis fractureassociatedwiththedecreaseofbonemassandthe ofmicroarchitec- quence．Osteoporostic impairment ture．Thebasicresearchaboutbonemicrostructureand revealmechanismoffracture． microdamagemay the The ofbonestructurecanbedetected methodinclinical itis to change usingimaging practice，whilepossible fractureriskcombinedwith offiniteelement markersofbonemetabolic predict application analysis．The andfractureriskassessment are ofbone rolesinthe pathway tool，whichindependentstructure，playpositive andcontrolof fracture．Concernaboutthelife of withfracture earlyprevention osteoporostic qualitiespatients reducethe ofrefracture．Newresearchdirectionsof fracturesrisksassessment may possibility osteoporostic willbe theseresearch and initiated methods． drugscreening by turnover fracture；Microstructure；Bone