局部晚期直肠癌术后同步放化疗与化疗的疗效比较.pdfVIP

· 202 · 齐齐哈尔医学 院学报 2015年第 36卷第2期 JournalofQiqiharUniversityofMedicine，2015，Vo1．36，No．2 表2 A1组与A2组早期胰岛素分泌指数以及 B细胞胰岛素分泌功能的临床对比(面±s) (收稿 日期：2014—10-21) 局部晚期直肠癌术后 同步放化疗与化疗的疗效 比较 蒋 日月 裴红蕾 【摘要】 目的 比较术后同步放化疗与单纯化疗对局部晚期直肠癌的临床疗效及不 良反应。方 法 72例局部晚期直肠癌患者，其中观察组33例行术后同步放化疗 ，对照组39例行术后单纯化疗，比较 两组不 良反应、疗效及生活质量。结果 两组患者骨髓抑制、胃肠道反应及肝肾功能损害等不 良反应和生 活质量评分无显著差异(P0．05)。观察组患者3年局部复发率、无进展生存率及生存率均有延长趋势， 但差异无统计学意义 (P0．05)。结论 局部晚期直肠癌术后患者行同步放化疗是安全、可行 的治疗措 施 ，但其远期疗效有待更多大样本研究来进一步阐明。 【关键词】 晚期直肠癌；放化疗；化疗 Comparison ofpostoperativeconcurrentchemoradiotherapy and chemotherapy in treatmentfor locally advancedrectalcnacer JiangRi—yue，eta1． DepartmentofRadiotherapy，theThirdA3~liatedHospitalof Soochow University，Changzhou212003，China． 【Abstract】 Objective Tocomparetheclinicalefficacyandsideeffectsofpostoperativeconcurrent chemoradiotherapyandchemotherapyinthetreatmentforlocallyadvancedrectalcancer．Methods Seventy—two patientswithlocallyadvancedrectalcancerwereenrolledinthepresentstudy，inwhich 33 patientsreceived postoperativeconcurrentchemoradiotherapy(observationgroup)andtheothers(39patients)onlyreceived postoperativechemotherapy(controlgroup)．Thesideeffects，clinicalefficacyandqualiuoflifewereevaluated， andthescoreswere comparedbetweentheabovementionedtwogroups．Results Comparedwiththecontrol group，patientsinhteobservationgroupshowednostatisticallysignificantdifferenceintherateof gastrointestinal sideeffects，bonemarrowsuppression，hepaticand／orrenaldysfunctionandquali~oflife(P0．05)．Although thedifierencesbetweenthetwogroupsintheratesof3一yearlocalfailure．progression．freesurvival andsurvival wasnostaticallymeanings，theobservationrgoupshowedalittlehigherthanhtecontrolrgoup (P0．05)． Conclusions Th e concurrentchemoradiotherapywaswelltolerated and demonstrated encouragingefficacyin patientswith locally advanced rectalcancer．However，future studieswith large sample