淫羊藿、骨碎补对去卵巢大鼠骨密度的影响研究.docVIP

淫羊藿、骨碎补对去卵巢大鼠骨密度的影响研究 黑龙江省中医研究院 穆军 [摘要]目的：观察补肾中药淫羊藿、骨碎补单用及合用对SD去卵巢大鼠骨密度和骨矿质含量可能产生的影响。方法：将40只8月龄的雌性SD大鼠随机分为：正常组、病理组、淫羊藿组、骨碎补组以及淫羊藿+骨碎组5组，通过造模及分别用药12周后，用双能X射线骨密度测量仪测定骨密度及骨矿物质含量，右股骨用于测量骨密度指标，左股骨测量骨钙含量，比较各组间差异。结果：淫羊藿组、骨碎补组及淫羊藿+骨碎补组均可不同程度地抑制去卵巢大鼠股骨的BMD和BMC的下降(P0.05)，只有淫羊藿+骨碎补组可明显将增加BMD和BMC的含量，存在统计学差异(P0.01)；结论：各药物治疗组对去卵巢雌性大鼠的骨质疏松症有一定疗效，且淫羊藿、骨碎补两者合用疗效更佳。 [关键词]淫羊藿；骨碎补；骨密度；骨矿物质含量 The effect of barrenwort and drynaria fortunei on bone mineral density in ovariectomized rats ********* Abstract Objective：To observe the kidney medicine barrenwort，drynaria fortunei to go alone and share ovariectomized SD rats osteoporosis influence.Methods:The only 8 months for the next 40 female SD rats randomly divided into:that of normal and p- athological group,barrenwort group,of drynaria fortunei and barrenwort close drynaria fortunei 5 groups.Through respectively made mould and drug testing after 12 weeks, each BMDand BMC were compared the difference between groups.After the bone m- ineral density and the bone mineral content were measured by dual-energy X-ray abs- orptiometry. The bone mineral density of right femur and the calcium of left femur w- ere measured.Result:Barrenwort group,drynaria fortunei group,and barrenwort close of drynaria fortunei different degree inhibit ovariectomized rats to femoral BMD drop (P0.05),but barrenwort close of drynaria fortunei can significantly increases bone mineral,bone mineral content .The difference was statistically significant (P0.01) Conclusion:Each drug group had to go to the female rat osteoporosis have certain curative effect ,and barrenwort both drynaria fortunei better share curative effect. Kye word: Barrenwort ; Drynaria fortunei ;Bone mineral density; Bone mineral content 骨质疏松（osteoporosis）是多种原因引起的一组骨病，骨组织有正常的钙化，钙盐与基质呈正常比例，以单位体积内骨组织量减少为特点的代谢性骨病变。骨质疏松症主要分为原发性骨质疏松症和继发性骨质疏松症。原发性骨质疏松症包括绝经后骨质疏松症（Ⅰ型）和老年性骨质疏松症（Ⅱ型），占骨质疏松发病总数的85%-90%，是中老年人，尤其是绝经后妇女常见的疾病。随着社会的老龄化，骨质疏松的发生率及对老年人群健康的危害已经越来越受到重视，在预防和治疗方面做了大量的研究。淫羊藿和骨碎补是中医常用的滋补药材，自古以来被我国中医作为补肾强骨的药材在临床治