双黄连注射剂与西药配伍研究的系统评价.pdfVIP

Review Articles Chin J Evid-based Med 2010, 10(2): 148-155 双黄连注射剂与西药配伍研究的系统评价△ * 张俊华  商洪才  郑文科  胡  晶  徐宏娟  王  辉  张  莉  任  明  张伯礼 天津中医药大学（天津 300193 ） 摘要  目的 探讨研究双黄连注射剂与西药注射剂和配伍宜忌，为双黄连注射剂的临床合理使用提供依据。 方法 全面收集双黄连注射剂（水针和粉针）与西药注射剂配伍的实验室和临床研究，提取有关双黄连剂型与用量、 配伍药物及用量、输液类型、配制液理化检测指标以及药物代谢、药效指标和不良反应等数据，按照配伍药物的类 别进行分类，描述性分析其物理性状、化学成分、药物代谢和安全性等，并据此评价配伍的宜忌。结果 共纳入60 篇文献，其中实验研究38 篇，1999 ～2002 年间发表者占总数的50%。所有研究共涉及西药注射剂53 个，并以与 β内酰胺类、氨基甙类及喹诺酮类抗生素配伍的研究为多，共发现31 个配伍禁忌。本系统评价结果还显示，现有实 验研究指标选择片面，在今后的研究设计中应予注意。结论 双黄连注射剂与西药针剂存在广泛配伍禁忌，在没 有研究清楚前，不可盲目配伍使用。现有中药注射剂与其他药物配伍的基础研究还很薄弱，企业应加强组织研究， 主动收集上市后研究的数据，不断完善说明书。 关键词 双黄连；中药注射剂；配伍禁忌；相互作用；系统评价 Systematic Review on the Compatibility of Shuanghuanglian Injection Combined with Western Medical Injections△ * ZHANG Jun-hua, SHANG Hong-cai , ZHENG Wen-ke, HU Jing, XU Hong-juan, WANG Hui, ZHANG Li, REN Ming, ZHANG Bo-li Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China Abstract Objective Shuanghuanglian injection (SHLI) is a typical Chinese medicine injection which has been used for more than 20 years. This study aims to investigate the compatibility of SHLI with western intravenous agents. Methods An extensive literature search was executed to identify all experimental tests and clinical reports on the topics. Data on the types of infusion solutions and western medical injections, usage and dosage, outcome measures for physical and chemical properties, and changes of drug effect were searched for. The included data was analyzed and described by the category of included western drugs. Compatibility was tested through integrating the evaluations of physical properties, chemical composition, drug metabolism, and safety. Results Sixty articles (38 experimental tests and 22 clinical reports) were included after screening. Fifty–three western medical injec