爱普列特对前列腺5α还原酶活性及雄激素受体水平的影响.pdfVIP

论  著 • 原始研究 中国循证医学杂志2008, 8(12): 1047 ～1049 爱普列特对前列腺5α-还原酶活性及 雄激素受体水平的影响 * 龚志勇  崔  曙  鲜述彦  邓显忠  王继忠   川北医学院附属医院泌尿外科 （四川南充 637000 ） 摘要  目的 探索爱普列特对前列腺组织 5α-还原酶活性及雄激素受体水平的影响。方法 将 40 例确诊为 良性前列腺增生患者随机分为两组，每组各 20 例。试验组服用爱普列特以及特拉唑嗪，对照组只服用特拉唑嗪。 两周后全部患者行手术取前列腺组织标本，用免疫组化的方法检测 40 个前列腺标本中 5α-还原酶的活性及雄激素 受体水平。结果 试验组前列腺标本中 5α-还原酶染色呈弱阳性或阴性，对照组前列腺标本中 5α-还原酶染色呈 强阳性。40 例前列腺标本雄激素受体染色均呈强阳性。结论 口服爱普列特可明显抑制前列腺内 5α-还原酶的 活性，但对前列腺内雄激素受体水平无明显影响。 关键词 爱普列特；前列腺；5α-还原酶；雄激素受体 Effect of Epristeride on 5-Alpha-Reductase Activity and Androgen Receptor Level in Prostate Tissue * GONG Zhi-yong, CUI Shu , XIAN Shu-yan, DENG Xian-zhong, WANG Ji-zhong Department of Urology, Hospital Attached to North Sichuan Medical College, Nanchong 637000, China Abstract Objective To investigate the effect of epristeride on 5-alpha-reductase activity and androgen receptor levels in prostate tissue. Methods Forty patients with benign prostate hyperplasia were randomly divided into the trial group and the control group with 20 in each group. Patients in the trial group were administered oral epristeride and terazosin, while those in the control group were given just terazosin. All patients underwent trans-urethral resection of the prostate after two weeks, and then the 40 samples of prostate were tested immunohistochemically for 5-alpha-reductase activities and androgen receptor levels. Results The 5-alpha-reductase in prostate tissue was not stained or lightly stained in the trial group, while it was heavily stained in the control group. The androgen receptor in prostate tissue was heavily stained in both groups. Conclusion Oral epristeride can inhibit the activity of 5-alpha-redutase in prostate tissue, but it has no obvious effect on the androgen receptor level in prostate tissue. Key words Epristeride; Prostate; 5-alpha-reductase; Androgen rece