不同蒽环类抗生素在急性早幼粒细胞白血病治疗中的应用比较.pdfVIP

·60· 不同蒽环类抗生素在急性早幼粒细胞白血病治疗中的应用比较 (432100孝感)湖北省孝感市中心医院二内科程利民 【摘要】 目的观察米托葸醌、吡喃阿霉素和去甲氧柔红霉素3种蒽环类抗生素在急性早幼粒细胞白血病治疗中的效果 和毒副作用的差异。方法将60例急性早幼粒细胞白血病患者随机分为3组，分别给予米托葸醌、吡喃阿霉素和去甲氧柔红 霉素治疗，比较其治疗效果和毒副作用。结果米托葸醌、吡喃阿霉素和去甲氧柔红霉素3组的治疗总有效率分别为75．0％、 (P0．05)。结论米托蒽醌、吡喃阿霉素和去甲氧柔红霉素3种蒽环类抗生素均可用于治疗急性早幼粒细胞白血病，去甲 氧柔红霉素抗肿瘤活性高，毒副作用较低，有推广价值。 【关键词】抗生素；蒽环类；白血病；早幼粒细胞；急性 The antibioticsinthetreatment磺acuteleukemia．CHENG comparison试anthracycline promyelocytic nPSecond Center 432100，C^ina of Medicine，XiaoganHospital，Xiaogan Toobservethedifferencesofcurativeeffectsandadversereactionsof [Abstract]Objective idarubicin(IDA)onwithacute with． tetrahydropyranyladriamycin(THP)andpatients promyelocytic Methods withAPL dividedintothree with were treatedMIz，THP Sixtypatients randomly groups Thecurativeeffectsandadversereactionsofthesethree were Thetotaleffectiverates groupscompared．Results ofMIZ． THPandIDA were75．0％，75．0％and incidenceof inⅢlA group 80．0％，respectively(PO．05)．Thecardiotoxicitygroup was lowerthanth08eofMIZandTHP MIZ，THPand口DAcanallbeusedtOtreat significantly group(P0．05)．Conclusion APLmlAhas suchaS anti-tumor adverse itisworth in advantageshigh activity，lessreactions，SO clinic． applying [Key 10 100～200 [-IDA 急性早幼粒细胞白血病(APL)的治疗近几年进 mg／(m2·d)×3+Ara-Crag／ (rn2·d)×7]方案进行诱导缓解治疗。完全缓解 展较快，随着维甲酸(ATRA)治疗APL获得巨大成 后，使用中剂量Ara—C(1．o～2．0 功，蒽环类抗生素单药或联合ATRA或联合阿糖胞