加味四物汤对荷骨肉瘤小鼠抑瘤作用的研究.pdfVIP

味四物汤对荷骨肉瘤小鼠抑瘤作用的研究 ﹡ 黄永明 刘金文 何仁荣 许少健 石宇雄 杜明昌 （广东省中医院骨病骨肿瘤科，广州 510120） 【摘要】 目的 探讨 味四物汤对荷骨肉瘤小鼠肿瘤体内浸润生长和免疫器官的影 响。方法：建立KHOS成骨肉瘤原位移植模型，通过加味四物汤灌胃干预动物模型，观察其对 移植瘤的生长情况及其对肝 脾组织脏器的影响。结果：加味四物汤高剂量组有明显的抑瘤 效果(P0.01)，中 低剂量组无明显抑瘤作用(P0.05)，加味四物汤高剂量组27.74%的抑瘤 率高于中 低剂量组的3.98% 9.24%。肝 脾组织脏器指数变化等方面无统计学差异(P0.05)。 结论：加味四物汤可以抑制荷瘤小鼠体内肿瘤的生长，但与药物浓度相关。对荷瘤小鼠的肝 脾等免疫器官无明显抑制作用。 键词； 味四物汤；骨肉瘤；移植性肿瘤；抗肿瘤作用 The Anti-tumor effects of modified Decoction of Four Drugs on the osteosarcoma mouse Huang Yongming;Liu Jingwen,He Renrong,Xu Shaojian, Shi Yuxiong ,Du Mingcan （Osteopathy bone tumor Department of Guangdong Provincial Hospital of TCM 。 Guangzhou 510120） 【Abstract】 Objective To investigate the effect of modified Decoction of Four Drugs on the in vivo infiltrating growth of malignant bone tumor and immunity organ. Methods We build the mice orthotropic transplantation model of osteosarcoma KHOS. Observe the growth of the transplantation tumor after treating with the modified Decoction of Four Drugs by intragastric administration of the animal models; As well as the changes of animal weights and their immune organ such as liver and spleen index were also investigated. Results High-dose modified Decoction of Four Drugs group has significant effect on restraining the proliferation of bone tumor cells(P0.01),while middle and low-dose groups have no significant effect on restraining the