短时程突触可塑性的功能意义3.pdfVIP

1·74 · 生物化学与生物物理进展 　　Prog. Biochem. Biophys. 　　　　　2000 ; 27 (2) Biol Chem , 1995 , 270 (8) : 3565～3573 site of proline residue located internally in a peptide. 25 Umemura K , Kondo K , Ikeda Y , et al . Pharmacokinetics and safety of Z321 , a novel specific orally active prolyl endopeptidase It can hydrolyse several peptide hormones and inhibitor , in healthy male volunteers. J Clin Pharmacol , 1999 , 39 neuotransmitters , so abnormal raise and decrease of (5) : 462～470 PEP activity would result in diseases related to memory and cognition. Specific inhibitor for example Progress in the Studies of Prolyl Endopeptidase. L I J TP4819 shows a good pharmaceutical effect in Min , CHEN ChangQing ( S hanghai Research reversing scopolamineinduced amnesia in rats. The Center of B iotechnology , The Chinese A cadem y of analysis of crystral structure of PEP from porcine Sciences , S hanghai 200233 , China) . muscle has greatly promoted the research on PEP. Abstract 　 Prolyl endopeptidase ( PEP ) [ EC Key words 　prolyl endopeptidase , serine protease , 34 21 26] is a new class of serine protease , which inhibitor , crystal structure is capable of hydrolyzing a substrate on the carboxyl 短时程突触可塑性的功能意义 贾 　凡 　周逸峰1) ( 中国科学技术大学生命科学学院, 合肥 230026) 摘要 　短时程的突触可塑性是突触可塑性的一种重要表现形式 ,