祛浊化痰中药对AS家兔血管成形术后炎性因子表达的影响_王凤荣.pdfVIP

第 29 卷 第 2期 Vol. 29 No. 2 2 0 1 1年 2 月 CH INESE ARCH IVES O F TRAD IT OI NA L CH INESE M ED CI INE Feb. 2 0 1 1 AS 1 1 2 王凤荣, 王帅 , 孙淼 ( 1. , 110032; 2. , 110001) : 目的: 观察祛浊化痰中药(通脉颗粒) 对高脂饮食兔 管成形术后炎性因子 hs- CRPICAM - 1NF - KB 的影响方法:选择新西兰大耳白兔 50只随机分为空白组模型组中药组西药组中西药组各 10只, 通 过喂养高脂饲料建立家兔AS模型, 周后造 管内皮球囊拉伤模型, 测定 hs- CRP含量及各组 ICAM - 1NF- KBmRNA表达结果: 通脉颗粒可显著下调高脂饮食兔 管成形术后病灶中hs- CRP含量, 且能明显降低家兔 清 ICAM - 1NF- KBmRNA表达水平 ( P 0. 05) 结论: 通脉颗粒能减少AS斑块内的炎性因子表达, 并可抑 制 管内皮拉伤后相关炎性因子的表达, 以减少AS的形成及防止术后再狭窄其作用机制可能与调脂抗炎的 作用有关 :祛浊化痰法; 细胞黏附分子( ICAM - 1); 高敏 C反应蛋白( hs- CRP); 核因子 - KB( NF- KB) : R2 5. 5 : A : 1673- 7717( 2011) 02- 0241- 03 Turbid Ph legm R em oving R abb its by H igh Fat D iet- re lated Factors A fter Angiop lasty of In flamm atory 1 1 2 WANG Feng-rong , WANG Shuai, SUN M iao ( 1. Departm ent of Cardiology, A ffiliated H ospital ofL iaoning University of TCM, Shenyang 110032, L iaoning, China; 2. ChinaM edicalUniversity, Shenyang 110001, L iaoning, China) A bstrac :t O bj ect iv e: To observe the cured turbid ph legm m edicine ( Tongm ai particles) on the h igh fat diet rabb its after balloon angiop lasty inflamm ation- associated factor hs- CRP, ICAM - 1, NF- kB effects. M ethod s: 50 N ew Zeal- andw hite rabb itsw ere random ly divided into blank group, m odel group, group, western m ed icine group, in the western group 10, through the high fat d iet rabb its AS model, to the high fat diet for w eeks create vas