p300CBP及其相关因子PCAF和转录调控1.pdfVIP

ISSN 中国生物化学与分子生物学报 2009 年 10 月 CN 　113870Q Chinese Journal of Biochemistry and Molecular Biology 25 ( 10) :877～882 ·综述 · p300CBP 及其相关因子 PCAF 与转录调控 林娟玉 , 　黄 　翔 , 　韩爱东 ( 厦门大学生命科学学院 ,厦门　361005) 摘要 　p300CBP 及其相关因子 PCAF 具有乙酰转移酶活性 ,能通过乙酰化组蛋白和非组蛋白的方 式参与基因的转录调控. 同时 ,它们也能介导多种转录因子. 与大多数典型的转录辅激活子相同 , 它们能在转录因子和基本转录复合物之间起到桥梁作用. p300CBP 与细胞周期调控 、细胞凋亡以 及癌症的发生等过程之间有着直接的联系. 本文概括介绍了p300CBP 与 PCAF 的基本特性 ,并简要 介绍它们与其它蛋白之间的相互作用 ,特别是 E1A 的最新研究进展. 关键词 　p300CBP ;PCAF ;组蛋白修饰 ;组蛋白乙酰化酶 ;转录调控 中图分类号 　Q78 p300CBP and p300CBPassociated Factor with Transcriptional Regulation L IN JuanYu , HUAN G Xiang , HAN AiDong ( School of L if e Sciences , Xiamen University , Xiamen 　361005 , China) Abstract 　p300CBP and p300CBPassociated factor ( PCAF) exert an intrinsic histone acetyltransferase ( HAT) activity . Histones and nonhistone proteins were acetylated to regulate transcriptions of specific sets of genes and interact with various transcription factors. Like the most classical transcriptional coactivators , p300 CBP and PCAF can also bridge the transcriptional factors to the basal transcriptional complex to maintain the appropriate levels of gene activities during various physiological processes , such as cell cycle , apoptosis and carcinogenesis. The review focuses on the basic characteristics of p300CBP and PCAF , and the specific interactions with their protein partners in tumor progression , such as E1A , Rb and p 53 are also discussed . Key words 　 p300CBP ; p300CBPassociated factor ( PCAF )