茵陈蒿油对小鼠急性酒精性肝损伤的保护作用.pdfVIP

of 18 No8 1498 中国卫生检验杂志2008年8月第18卷第8期ChineseJournalHealt}l 2008；Vol LaboratoryTechnology，Aug 【论著】 茵陈蒿油对小鼠急性酒精性肝损伤的保护作用 唐慧，周雯，李慧 (山东省疾病预防控制中心，济南250014) [摘要] 目的：研究茵陈蒿油对小鼠急性酒精肝损伤的影响。方法：小鼠一次性经口给予50％乙醇，建立急性酒精性肝 肝组织病理学变化。结果：茵陈蒿油使酒精肝损伤小鼠的MDA含量明显下降，GSH含量明显升高，TG含量下降，明显改 善肝组织损伤的程度，与模型组比较差异有统计学意义(P0．01)。结论：茵陈蒿油对酒精肝损伤具有一定的保护作用。 [关键词]茵陈蒿油；酒精；肝损伤 [中图分类号]R114 [文献标识码]A [文章编号] 1004—8685(2008)08—1498—03 ProtectiveeffectofYinchenhaooildecoctiononmicewith liver induced acute injury by alcoh01 ％昭Hui，ZhouWen，“Hui CenterforDiseaseControland Prevention，Jinan (Shandong 250014，China) observethe effectofYinehenhaooildecoctionontheacuteliver inducedalcohol [Abstract]Objective：To protective injury by inmice．Methods：Acuteliver modelwasinduced50％alcohol levelsof andTGintheliver injury by givenorally．The MDA，GSH tissueweremeasured．Liverindexwascalculatedand ofthelivertissuewereobservedunder changes optic pathological oil reducedMDAand GSHinthelivertissueand amcliora— significantly TG，increased markedly microscope．Results：Yinchenhao tedtheliver oilcan acuteliver inducedalcoholinmice against injury by damage(P0．01)．Condusion：Yinchenhaoprotect andthemechanismofwhichberelatedtoits of may a