肿瘤干细胞的多样性起源和其相应机制的研究进展_刘增军.pdfVIP

中中国癌症杂志国癌症杂志》22011年第21卷第3期011年第21卷第3期 《 223636 CCHINA ONCOLOGY HINA ONCOLOGY 22011 Vol.21 No.3011 Vol.21 No.3 肿瘤干细胞的多样性起源及其相应机制 的研究进展 刘增军 综述　沈赞　姚阳 审校 上海交通大学附属第六人民医院肿瘤内科，上海 200233 　　［摘要］　肿瘤干细胞理论认为绝大多数肿瘤起源于肿瘤干细胞，且只有肿瘤干细胞具有无限增殖、多向 分化和体内外形成异质性肿瘤的能力，然而关于肿瘤干细胞的起源仍有争论。目前的研究提示肿瘤干细胞的起 源或许是多样性的，可以起源于组织干细胞、间充质干细胞以及不同程度分化了的组织细胞，甚至非成瘤的普 通肿瘤细胞在一定条件下也可能转化成肿瘤干细胞。本文就肿瘤干细胞的多样性起源及其相应机制作一综述。 ［关键词］ 　　 　肿瘤干细胞；　缺氧；　转移；　上皮间质转换 　　DOI：10.3969/j.issn.1007-3969.2011.03.017 　　中图分类号：R730.2　　文献标识码：A　　文章编号：1007-3639(2011)03-0236-05 Recent progress in the research on the various origins of cancer stem cells and their relevant mechanisms　LIU Zeng-jun, SHEN Zan, YAO Yang (Department of Oncology, The Sixth Peoples Hospital, Medical College of Shanghai Jiao Tong University, Shanghai 200233, China) Correspondence to：YAO Yang　E-mail：yangyao_6@ 　　［Abstract ］ The cancer stem cell theory proposes that most tumors are derived from cancer stem cells, which have the capacity to unlimitedly proliferate, multipotently differentiate, and ultimately form heterogeneous tumors in vivo. However the origin of cancer stem cells remains controversial. Recent studies suggested that there may be various candidates from which cancer stem cells originate, such as normal tissue stem cells, mesenchymal stem cells, differentiated tissue cells or even non-tumorigenic tumor cells, all manifesting under specifi c conditions. Therefore we made a concise review about recent progress in recent research on various origins of cancer stem cells and their relevant mechanisms. 　［Key words ］　Cancer stem cell; Hypoxia; Metastasis; Epithelial-mesenchymal tran