不同添加剂处理样本对高效液相色谱法测定血氯氮平及其代谢产物浓度的影响.pdf

2009 11 24 11 Lab oratoryM dicin , Nov m b r 2009, Vol 24. No 11. # 799# : 1673-8640 ( 2009) 11-0799-05 : R971 : A 郭新胜, 王冀康, 师天元, 姜 锋, 张红亚 (, 453002) : ( HPLC)( CZP) ( N-CZP) CZP , , HP-1100H PLC CZPN-CZP , CZPN-CZP (P 0. 00 1) CZPN-CZP (P 0. 05); CZPN-CZP (P 0. 01~ 0. 00 1) , 4 e 24 h, CZP N-CZP(P 0. 05), (P 0. 05) 4 e 24 h, CZP(P 0. 05), N-CZP (P 0. 05); CZPN-CZP (P 0. 05); (P 0. 05) CZPN-CZP , , , ; HPLC CZPN-CZP , : ; ; ; ; ; ; Influence of differentadditives to the concentrations of clozapine and itsmetabolite in blood samplesmeas- ured by high performance liquid chromatography GUO X insheng, WANG J ikang, SH I T ianyuan, JIAN G F eng, ZHAN G H ongya. (D ep a tm en t of Cent al Labo ato y, the Second Aff iliated H osp ital of X inx iang M ed ical Un ive s ity, H enan X inx iang 453002, China) Abstract: Objective T o xp lor th f asib ility of d t rm in ing th conc ntrations of clozapin ( CZP) and norcloz- ap in ( N-CZP) in blood samp l s tr at d w ith various additiv s by h igh p rform anc liquid chromatography ( HPLC). M ethods Th b lood sam pl s of pati nts tr at d w ith CZP w hich has r ach d a st ady stat w r coll ct d in four d iff r- nt vacuum tub s: on no additiv , and 3 tub s w ith h parin sod ium anti-coagu lant, coagulant, s paration g l, r sp c- tiv ly. Th CZP and N-CZP conc ntrations w r d t rm in d by H PLC ( M od lH P-1100). Th d iff r nc s of th r sults w r com par d. Results Th r w r sign ifican t d iff r nc s in CZP and N-CZP conc ntrat