生物可降解载药纤维的制备_特征表征及释药特性的研究.pdfVIP

25 4 Vol. 25 No.4 2008 8 Journal of Biomedical Engineering August 2008 * 1 1 2 高 昊 平其能 顾月清 1 ( 中国药科大学 药剂学教研室, 南京2 10038) 2 ( 中国药科大学 生物医学工程实验室, 南京210038) , ( PLLA) , ( SEM) , ( DSC) ( FT IR) , ( HPLC) , ( UV) PLLA , ; , ( PLLA) R31808 A 100155 15( 2008) Fabrication, Characterization and Drug Release Characteristics of Drug Loaded Poly (Llactic acid) Fiber 1 1 2 Gao Hao Ping Qineng Gu ueqing 1 ( Dep art men t of Phar maceuti cs, Chi na Pharmaceut ical Univ ersi ty , N anj i ng 210038 , Chi na) 2 ( The Ce nter of Biotechni cs, Chi na Pharmaceut ical Univ ersi ty , N anj i ng 210038, Chi na) Abstract T o de elop a long term released and implantable biodegradable fiber carrier for hydrophobic drug incorpo ration, fibers were fabricated by organic phase separation method. The structure of the fiber w as obser ed by scanning electron microscopy and the state of the drug dispersed in the polymer w as measured by differential scanning colorimetry ( DSC) and Fou ier transform infrared spectroscopy( FT IR) . The drug loading content and release profiles w ere deter mined by high performance liquid chromatography ( H PLC) and ultra iolet spectrophotometry, respecti ely . Blank and drug loaded fibers were successfully fabricated and the drug was entirely encapsulated into the fiber. The drug w as dis persed in the polymer w ith minicrystal and noncrystal form. The drug release profile w as long term sustained and co