硫必利和氟哌啶醇治疗抽动秽语综合征的临床疗效和安全性比较.pdfVIP

现代药物与临床 Drugs Clinic 第 28 卷 第 6 期 2013 年 11 月 • 919 • 硫必利和氟哌啶醇治疗抽动秽语综合征的临床疗效和安全性比较 李红梅 连云港市第一人民医院 儿科，江苏 连云港 222002 摘 要：目的 比较硫必利和氟哌啶醇治疗抽动秽语综合征的临床疗效和安全性。方法 2010 年 1 月—2013 年 1 月在连云 港市第一人民医院儿科门诊就诊的 84 例抽动秽语综合征患儿随机分为治疗组（42 例）和对照组（42 例），对照组口服氟哌 啶醇 0.5～4.0 mg/次，2 次/d ；治疗组口服硫必利 50～100 mg/次，3 次/d 。两组均持续治疗 10 周。在治疗前，治疗第 2 、4 、 6、8、10 周分别对两组患者进行 YGTSS 和 TESS 评分，比较其临床疗效和不良反应。结果 结果显示，两组的 YGTSS 评 分与治疗前相比均显著下降，差异均有统计学意义（P ＜0.05 ），但治疗后两组的YGTSS 评分差异无统计学意义。各观察时 间点治疗组的TESS 评分均显著低于对照组，两组差异有统计学意义（P ＜0.05 ）。结论 硫必利治疗抽动秽语综合征与氟哌 啶醇的临床疗效相似，但硫必利的不良反应相对较小，安全性和耐受性较好，值得临床推广应用。 关键词：硫必利；氟哌啶醇；抽动秽语综合征 中图分类号：R985 文献标志码：A 文章编号：1674 - 5515(2013)06 - 0919 - 03 DOI: 10.7501/j.issn.1674-5515.2013.06.026 Comparison of clinical efficacy and safety between tiapride and haloperidol in treatment of Tourette syndrome LI Hong-mei The First People’s Hospital of Lianyungang, Lianyungang 222002, China Abstract: Objective To compare the curative effect and safety of tiapride and haloperidol in the treatment of Tourette syndrome. Methods The patients (84 cases) diagnosed with Tourette syndrome in the First People’s Hospital of Lianyungang from January 2010 to January 2013 were randomly divided into treatment (42 cases) and control (42 cases) groups. The patients in the control group were po administered with haloperidol, 0.5—4.0 mg per time, twice daily. The patients in the treatment group were po administered with tiapride, 50—100 mg per time, three times a day. The treatments for the both groups were carried out for 10 weeks. Before the treatment and during the treatments in the weeks 2, 4, 6, 8, and 10, Yale global tic severity scale (YGTSS) and treatment emergent symptom scale (TESS) were used to evaluate the efficacy and adverse reaction of the two drugs. Results The YGTSS score in the