温阳解毒活血法治疗急性心肌梗死60例.pdfVIP

温阳解毒活血法治疗急性心肌梗死 60 例 洪永敦,吴兴波 （作者单位：广州中医药大学第一附属医院,广东广州 510405） 摘要：【目的】观察温阳解毒活血法对急性心肌梗死患者的临床干预效果，并探 讨其可能的机理。【方法】入选60例确诊为冠心病急性心肌梗死的病人，按1:1 随机分为治疗组和对照组，两组患者同时给予标准无差别的西医治疗，包括药物 治疗（氯吡格雷、阿司匹林，肝素或低分子肝素，β受体阻断剂，ACEI/ARB 等 药物）和PCI或静脉药物溶栓，以及糖尿病、高血压病和血脂异常等基础病的治 疗。治疗组在这基础上，予温阳解毒活血中药（柴胡10g、桂枝10g、黄芩15g、 连翘 15g、党参 20g、法夏 10g、薤白 15g、川芎 10g、丹参 15g、炙甘草 5g）， 水煎服，日一剂。治疗两周后，观察炎症因子的变化，以计分法比较两组治疗后 胸痛、胸闷、气短、心悸疲倦乏力、畏寒肢冷等症状及体征的改善情况。【结果】 经过两周的治疗，治疗组及对照组的临床疗效均达到较高的有效率（分别为 96.67%、93.33%）。治疗组在降低炎症因子及改善症状方面优于对照组。两组均 未发现明显的不良反应。 【结论】应用温阳解毒活血中药治疗心肌梗死患者，能 有效的降低患者的炎症反应及改善症状，显示了温阳解毒活血法治疗急性心肌梗 死的可行性。 关键词 急性心肌梗死；温阳解毒活血；中药；临床研究 the Efficacy of Warming-Yang,Removing-Toxicity and Activating-Blood therapy in Acute Myocardial Infarction of 60 cases Hong yongdun, Wu xingbo (writers’ working places: Guangzhou university of traditional Chinese medicine Affiliated No. 1 hospital, Guangdong Guangzhou 510405) ABSTRACT Objectiive To observe the efficacy of Warming-Yang,Removing-Toxicity and Activating-Blood therapy therapy in Acute Myocardial Infarction(AMI) ， and to explore its possible mechanism .To confirm the feasibility of Warming-Yang,Removing-Toxicity and Activating-Blood therapy treating AMI. Methods 60 cases of AMI patients were randomly divided into two groups： experimental group and control group.All the patients of two groups were given standard undifferentiated treatment of the modern medicine,including：general medical treatment such as drug treatment （Clopidogrel，Aspirin,UFH/LMWH,β-receptor blocker,ACEI/ARB etc.）and PCI or Intravenous thromolysis,the treatment of other related complication，for example Heyertension，Diabetes and Lipid disorders.At the same time,patients of the experimental group were given the decoction of Warming-Yang,Removing-Toxicity and Activating-Blood Chinese Herbs