银杏叶胶囊联合认知训练治疗稳定期慢性阻塞性肺病患者认知功能障碍临床观察.pdfVIP

银杏叶胶囊联合认知训练 治疗稳定期慢性阻塞性肺病患者 认知功能障碍临床观察 顾晓燕，张丽玲，蒋德升，于天培，李树猛 解放军第四五四医院南京210002 摘要 目的观察银杏叶胶囊联合认知训练对稳定期慢性阻塞性肺疾病(COPD)患者认知 功能障碍的影响，并初步探讨其作用机制。方法60例稳定期COPD患者随机分为对照组 和干预组，各30例，对照组采用常规药物治疗，干预组在此基础上给予口服银杏叶胶囊联 合认知训练，观察3个月，对两组患者治疗前后简易智能精神状态检查量表(MMSE)和蒙 特利尔认知评估量表(MoCA)评分进行比较分析，并采用ELISA法检测治疗前后患者外周 静脉血清S100B水平。结果与治疗前相比，干预组治疗后的MMSE和MoCA评分明显 提高(均P0．05)，而外周静脉血清S100B水平显著降低(P0．05o但对照组治疗前后MMSE、 改善COPD患者的认知功能，可能与降低患者血清中S100B水平有关。认知功能的改善对 提高患者的生活质量具有十分重要意义。 关键词慢性阻塞性肺疾病；认知功能；银杏叶；认知训练 Effectsof biloba and on in Ginkgo cognitive cognitive patients capsules training dysfunction withstablechronicobstructive disease pulmonary Gu Xiao-yah，ZhangLi-ling，JiangDe-sheng，YuTian-pei，LiShu-meng． To theeffects and Abstract of biloba Objectiveinvestigate Ginkgocapsulescognitivetraining on in withstablechronicobstructive disease．Method： cognitivedysfunctionpatients pulmonary casesof withstableCOPDwere dividedintotwo Sixty patients randomly groups(eachgroup 30 received consistedof cases)．Both medicine training groups thempy．Meanwhile，thegroup receivedthe biloba and for3months．TheMini-Mental cognitive Ginkgocapsulestherapy training State Montreal assessment(MoCA)assessmentwere Exam(MMSE)andcognitive performed beforeandafterthe levelsofS100Bwerealsoevaluatedineach trainingprogram．Serum useof biloba and subject．Results：Afterregular Ginkgo capsulestherapycognitivetraining