川芎嗪注射液联合葛根素治疗缺血性脑卒中临床研究.docVIP

川芎嗪注射液联合葛根素治疗缺血性脑卒中的临床研究 江苏省如皋市江安医院 226534 殷成华 [摘要] 目的 观察川芎嗪氯化钠注射液联合葛根素氯化钠注射液在缺血性脑卒中的临床疗效。方法 90例老年急性缺血性中风患者随机分为治疗组和对照组，治疗组用川芎嗪氯化钠注射液和葛根素氯化钠注射液联合治疗，对照组应用葛根素氯化钠注射液治疗。测定两组治疗前后血常规、肝肾功能、红细胞压积(Hct)、血液流变学和血浆纤维蛋白原水平(Feb)。结果 治疗组治疗有效率为82.2％，对照组有效率为44.4％，两组比较差异有统计学意义(P0.05)；治疗组治疗后神经功能缺损评分较入院时明显下降，与对照组比较差异有统计学意义(P0.05)；治疗组治疗后Hct无明显变化，血浆粘度、全血高切粘度、全血低切粘度和Feb均显著降低，治疗前后有显著性差异（P0.05）。结论 川芎嗪氯化钠注射液联合葛根素氯化钠注射液治疗缺血性脑卒中安全有效。 [关键词] 缺血性脑卒中；川芎嗪；葛根素 Clinical study of tetramethylpyrazine combined with puerarin in the treatment of acute ischemic stroke Yin cheng-hua.jianan hospital ,rugao city,Jiangsu province226534,china [Abstract] Objective To observe the clinical effect of tetramethylpyrazine combined with puerarin in the treatment of elderly acute ischemic stroke.Methods 90 cases of elderly acute ischemic stroke were randomly divided into treatment group and control group. The treatment group were treated with tetramethylpyrazine and puerarin. The control group were treated with puerarin only. The blood routine， liver function， kidney function， Hct， hemorheology and Feb were detected before and after treatment. Results The effective rate in treatment group was 82.2%，the control group was 44.4%，there was significant difference between two groups(P0.05); neurological deficit scores in treatment group decreased significantly， which had significant difference compared with control group(P0.05); Hct in treatment was unchanged after treatment，while plasma viscosity， blood viscosity and Feb decreased significantly after treatment（P0.05）.Conclusion Tetramethylpyrazine combined with puerarin are effective and safe in the treatment of elderly acute ischemic stroke. [Key words] ischemic stroke；tetramethylpyrazine； puerarin 　 　脑血管病是我国中老年人群的常见病、多发病，近年来呈上升和低龄化趋势，农村地区也日益突出。脑血管病的高发病率、高死亡率和高致残率不仅严重危害人民的健康和生活质量，同时也给国家及患者家庭带来沉重的医疗、经济和社会负担，是一个重要的公共卫生问题采用（福建省龙岩市天泉生化药业有限公司生产，批号：010275）200 mL(0.8 mg/mL)静脉滴注，每日1次注射液（江西东亚药业有限责任公司生产，批号：000573）200 mL(2 mg/mL)静脉滴注，每日1次采用注射液静脉滴注，每日1次两组均以15 d为1个疗程，治疗1个疗程。6、8 、