参麦注射液对外伤性脑损伤大鼠血清_省略_烯醇化酶一氧化氮内皮素水平的影响_张圣塨.pdfVIP

第 28 卷 第 3期 Vol. 28 No. 3 2 0 1 0 年 3月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE M ar. 2 0 1 0 张圣塨, 白 玉, 王良荣, 林丽娜 (, 325035) : 目的: 观察参麦注射液对大鼠外伤性 脑损伤 (TBI)血清神经元烯醇化酶( NSE)一氧化氮 (NO) 内皮素- 1(ET- 1)含量的影响,探讨其在治疗外伤性 脑损伤中的作用方法: 采用 Freeny 自由落体撞击方法 制作外伤性 脑损伤模型, 致伤后 1h单次腹腔注射参麦注射液 15m /kg为治疗组( C组), 腹腔注射等量生理盐 水为模型组( B组), 单纯开骨窗未损伤脑组织为假手术组( A组), 脑损伤后 6h10h24h及 3天检测大鼠血清 NSENO及 ET- 1的含量结果: 与 A组比较, B 组和 C 组 NSE 含量显著升高(P 0. 05), 3天基本恢复正常, ET - 1含量显著升高(P 0. 05), 高水平持续 3天, NO含量先下降24h 后明显上升 (P 0. 05), 高水平持续至 3d; 与 B 组比较, C组 NSEET- 1含量升高减轻 (P 0. 05), NO 含量早期下降减轻, 24h 后上升缓慢 (P 0. 05)结 论: 参麦注射液可通过减少ET- 1产生, 调节血清 NO含量达到减轻外伤性脑损伤作用 :脑损伤; 神经元烯醇化酶; 一氧化氮; 内皮素 - 1; 参麦 : R285. 5 : A : 1673- 7717( 2010) 03- 0583- 03 Effect of the Shenmai Injection on Serum Neuron S ecific Enolase, Nitrogen Monox di um and Endothelin- 1 foLlow ing Traumatci Brain Injury in a RatModel ZHANG Sheng-gong, BAI Yu, WANG iang-rong, IN i-na ( Departm ent ofAnesthesiology, the First A ffiliatedHospital ofW enzhouM edicalCollege, W enzhou 325035, Zhejiang, China) Abstrac:t O bj ectiv e: To investigate the effects of shenm ai injection on surum NSE, NO and ET- 1 in rats after trau- m atic brain injury (TBI) .M ethods: 72 SD ratsw ere random ly divided into three groups, the sham operation group(A) , the TBI group(B) and the shenm ai injection treated group(C). The latter two groups received free fall injury in the cere- bral hem isphere and received the sam e dose of intraperitoneal shenm aiand isotonicNa chloride at one hour post- injury, respectively. Serum NSE, NO and ET- 1 levelsw ere determ ined at 6h, 10h, 24h, 3d after TBI. R esults: The contents of NSE and ET- 1 in B and