肿瘤细胞低氧反应分子机制.pdfVIP

中华肿瘤防治杂志 2006 年 9 月第 13 卷第 17 期 　　CH IN J CAN CER PR EV TR EA T ,Sep t ember 2006 ,Vol . 13 　No . 17 ·135 1 · 综述 ·讲座 肿瘤细胞低氧反应的分子机制 1 2 李国元 , 　格 日力 1. 青海大学附属医院肿瘤内科 ,青海 西宁 81000 1 2 . 青海大学医学院高原医学研究中心 ,青海 西宁 8 1000 1 Molecular r e spon se s to hypoxia in tumor cell s 1 2 L I Guoy uan , GE R il i 1. D ep a rt ment of Oncology , A f f i l i ate d H osp i t al of Qi ng hai Uni ve rs i ty , X i ni ng 81000 1 , P. R . Chi na 2. R esea rch Cente r of H i g h A l ti t u de M e d ici ne , M e d ical Col leg e of Qi ng hai Uni ve rs i ty , X i ni ng 81000 1 , P. R . Chi na 【摘要】　由于肿瘤的高度浸润性和快速生 [ ABSTRACT] 　Highly aggressive , rapidly growing tumors are exposed to 长导致血液供应不足而产生肿瘤内低氧 。 hypoxia which occurs as a consequence of inadequate blood supply. Hypox 低氧在肿瘤细胞生理过程中起着许多重要 ia exert s a variety of influences on tumor cell biology. These are activation 作用 ,这些作用包括特定的信号转导通路 of certain signal transduction pathways and gene regulatory mechanisms , 的激活、基因调控 、基因突变介导的肿瘤细 induction of selection processes for gene mutations , tumor cell apopto sis 胞的恶性筛选 、肿瘤细胞凋亡和肿瘤血管 and tumor angiogenesis. Mo st of these mechanisms contribute to tumor 形成 。多种机制参与了肿瘤的进展 ,其中 progression . Therefore , tissue hypoxia has been regarded as a central factor 肿瘤组织内的低氧对于肿瘤进展和转移是 for tumor aggressiveness and metastasis. In this review , we summarize the 一个中心环节 。综述了最近有关肿瘤细胞 current knowledge about the molecular mechanisms induced by tumor cell 低氧诱导的分子机制方面的知识 ,重点描 hypoxia with a special emphasis on intracellular signal transduction , gene 述了细胞内信号转导、基因调控 、血管