高病毒载量肝癌患者(LAMADVETV三个药物比较,恩替卡韦最好).pdfVIP

Ann Surg Oncol (2013) 20:1482–1490 DOI 10.1245/s10434-012-2803-7 ORIGINAL ARTICLE – HEPATOBILIARY TUMORS Early Viral Suppression Predicts Good Postoperative Survivals in Patients with Hepatocellular Carcinoma with a High Baseline HBV-DNA Load 1 1 1 1 1 Gang Huang, MD , Yuan Yang, MD, PhD , Feng Shen, MD, PhD , Ze-ya Pan, MD, PhD , Si-yuan Fu, MD , Wan Yee Lau, MD, FRCS, FACS, FRACS(Hon)1,2 1 1 , Wei-ping Zhou, MD, PhD , and Meng-chao Wu, MD 1The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China; 2Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, People’s Republic of China ABSTRACT and high Ishak inflammation score were significant risk Purpose. To correlate early HBV-DNA suppression by factors of HCC recurrence. Also, tumor size [5 cm, sur- antiviral treatment with posthepatectomy long-term sur- gical margin \1 cm, presence of satellite nodules, presence vivals in patients with HBV-related hepatocellular of portal vein tumor thrombus and high Ishak fibrosis score carcinoma (HCC). were significant factors associated with poor postoperative Methods. A retrospective study was conducted on patients overall survival. On the other hand, an undetectable HBV- with a baseline HBV-DNA load of [2,000 IU/ml. The DNA level before week 24 was a significant protective cumulative rates of HBV-DNA undetectability at weeks 24 facto