帕金森病的相关因素和临床特征分析.pdfVIP

老年k学与保健2006年第12卷第4期 GleriatrHealthCare,2006,Vol.12.No.4 帕金森病的相关因素及临床特征分析 叶晓来 张 憬 王 瑛 吴逸雯 陈生弟 t摘要】目的 研究帕金森病(PD)的相关因素、首发症状、病程进展及相互之间的相关性，为疾病的预防提供 一些线索。方法 采用问卷调查、体格检查及量表评分分析176例PD患者的发病、病程进展及其影响因素。结果 176例患者，随年龄增长，以震颤起病者减少p(=0.012)，而以强直一少动起病者增多P(=0.034)。相关因素分析中，既 往有农药接触史、抑郁症史及油脂摄人较多的患者发病年龄偏早;吸烟、油脂摄人较多者易以震颤起病，而饮酒者略 少;饮绿茶者较少以强直一少动起病;体重指数(BMI)高者易以混合型起病，而喜食油炸食品者较少以混合型起病， 但以上因素不影响病程进展。结论 生活习惯、精神因素、环境因素对PD的发生、症状类型起不同的作用，但不影响 疾病的进展。 :关键词1帕金森病; 生活方式; 环境暴露 I中图分类号]8745f文献标识码]A I文章编号]1008-8296(2006)-04-0218-04 ANALYSISOFTHERELATIVEFACTORSANDTHECLINICAL.CHARACTERISTICSOFPAPW NSONDISEASE YeXmolal;ZhangJin_,WangYing,Wu31wen.ChenShengrh. DepartmentofNetrrology,Rui-./inHospital,ShanghaiJiaotongUniversitySchoololMerliCibe,.Shanghai200025,Chrmr A【bstract1ObjectiveToinvestigatetheclinicalcharacteristics,diseaseprogressionandrelatedfactorsinvolvedin patientswithParkinsondisease(PD)inordertoprovidesomecuestomakeapotentialprophylacticapproachforthedisease. Methods 176patientswithidiopathicParkinsondiseasewerestudiedbyquestionnaire,physicalexaminationandrating scales.ResultsTheincidenceoftremorwasgraduallyreducedwithagingP(=0.012).Incontrast,theincidenceofrigidity- akinesiawasgraduallyincreasedwithaging俨二0.03叼T·heearlyonsetofthediseasewasfoundinsuchpatientswhocontacted withthepesticide,sufferedfromdepression,andhadmoreintakeoffat.Theinitialsymptomoftremorwaslessdevelopedin thepatientswhodrankwine,butmoredevelopedinthepatientswhohadsmokingandtookmorefat.Thepatientswhodrank greenteahadlessakinesia-rigidity.Theincidenceoftremorandakinesia-rigiditywasincreasedinthepatientswithhighBMI, butdecreasedinthepatientswithmorefryintake.ConclusionsThefindingsuggeststhatlivinghabit,psychologicaland environmentalfactorswereinterferedwithageofonsetandvariousinitialsymptom(s),butnotwithth