左旋多巴诱发异动症大鼠模型黑质网状部电活动研究.pdfVIP

2008 16 6 663 徐 岩 张 婷 曹学兵 : ( LID)( SNr): SN r, LIDLIDMK80 1+ LID SN r: , SN r(P 0. 05) , (P 0. 05), LID LID(P 0. 05) MK 801+ LID, SN r LID(P 0. 05), (P 0. 05) LID, : SNr LID, SNr LID : R742. 5 : A : 1006- 351X ( 2008) 06- 0663- 03 Study on ElectrophysiologicalActivity of SubstantiaNigra pars ReticulaNeurons in the Levodopa- induced DyskinesiaRat X U Yan, ZH AN G T ing, CA O X u-bing Dep rtm ent of Neurology, Union H osp it l, T ongjiM ed ic l College, H u zhongUn iversity of Science nd T echnology, W uh n 430022, Ch in Abstract Objective: T o study the ch nges in electrophysiologic l ctivity of output nucle r of the b s l g ngli, subst nti n igr p rs reticu l ( SN r) in levodop - induced dysk inesi ( LID) r tm ode.l Methods:Recording electrodes w ere stereot cticly in- serted into dop m ine-denerv ted SN r, nd electroenceph logr ph w s used to record elecreophysiologic l ctivity of SNr before nd fter levodop tre tment in nom l group, non-LID group, LID group ndMK801+ LID group. Results: Before levodop tre tm ent, comp red to norm l group, w ve frequency of electroenceph logrm in SN r in other three groups w s reduced. After levodop tre t- m ent, com p red to before levodop tre tment, w ve frequency w s not sign ific ntly ch nged in nom l group, non-LID group nd LID group. MK-801 comb ined w ith levodop induced little stereotypy, nd w ve frequency w s incre sed comp red to LID group, nd w s not signific ntly different from nom l group. E lectroenceph logr m from LID group show ed few er int