The UK Biobank will.ppt

The UK Biobank will follow the health of half a million volunteers for many years (40-69 years) collect information on environmental and lifestyle factors link these to medical records and stored biological samples samples can be used for biochemical and genetic analysis Scientific Objectives Determine separate and combined effects of genes and environment on common causes of health and illness Nested case-control studies Prevalence studies Cohort studies (exposure based) Genotype-driven clinical investigation Biomarker detection as markers or risk factors How has UK Biobank been established? How will it work? Recruitment Assessment visits Questionnaire(s) Measurements IT systems Sample storage Ethical considerations Recruitment GP practices as sampling frames Exeter system identifies names and addresses of eligible individuals NHS agencies send personalised letters and leaflet Participants respond to UK Biobank Central booking and helpline The project is being designed with an accelerating recruitment plan…. Participants will come to assessment centres…… Assessment visits Dedicated peripatetic facilities 20-40 participants per day Receptionist, ward clerk, 2 nurses, 3 measurement staff 60 to 90 minutes in clinic GCP standard quality control Data collection IT and information Novel clinic systems – web-based always on-line Key-coded anonymous data storage HL 7 standards harmonised internationally GP2GP standard record for health record repository Samples will be collected from each participant Sample storage: automated retrieval at -80 degrees The Approach The need for collaboration Recruitment of Senior Management Team at Coordinating Centre ongoing Pilot studies start later in 2004 Full recruitment expected 2005 Current activities Piloting the clinical and molecular  processes Establishing the IT infrastructure and  clinical applications Developing the communications strategy to  support recruitment Writing the scientific protocol and pa