唾液分泌型免疫球蛋白A对口腔白假丝酵母菌黏附影响.docVIP

唾液分泌型免疫球蛋白A对口腔白假丝酵母菌黏附的影响 作者：陈昌荣，陈建钢 作者单位：1.赣南医学院第一附属医院口腔科 江西 南昌　341000；2.武汉大学中南医院口腔科 湖北 武汉 430071 【摘要】 目的 从唾液分泌型免疫球蛋白A（sIgA）的质量浓度和白假丝酵母菌黏附率变化的角度探讨人类免疫缺陷病毒（HIV）感染者易感染口腔假丝酵母菌病的原因。方法 检测唾液sIgA的质量浓度，并通过体外黏附试验观察白假丝酵母菌标准株（SCAL）和临床分离株（CCAL）在含和不含sIgA环境中与颊上皮细胞的黏附率，比较HIV感染组与健康对照组口腔内白假丝酵母菌的黏附率。结果 HIV感染组sIgA的质量浓度低于健康对照组（P＜0.05）；在含sIgA环境中，SCAL和CCAL的黏附率总体均值低于不含sIgA环境中SCAL和CCAL的黏附率总体均值，两组间差异有统计学意义（P=0.001）；在含sIgA环境中，HIV感染组口腔中的白假丝酵母菌的黏附率明显高于健康对照组（P＜0.05）。结论 HIV感染组易感染口腔假丝酵母菌病与唾液sIgA的质量浓度变化和白假丝酵母菌黏附力改变密切相关。 【关键词】 分泌型免疫球蛋白A； 白假丝酵母菌； 黏附； 人类免疫缺陷病毒； 获得性免疫缺陷综合征 In vitro study of oral Saccharomyces albicans in adhesion from human immunodeficiency virus/acquired immunodeficiency syndrome individuals CHEN Chang-rong1, CHEN Jian-gang2. （1. Dept. of Stomatology, TheFirst Affiliated Hospital of Gannan Medical School, Nanchang 341000, China; 2. Dept. of Stomatology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China） [Abstract] Objective To discuss the reason from which oral cavity Saccharomyces albicans get sick for beinginfected from the angle of looking at the human immunodeficiency virus（HIV）-infected persons and analyzingthe saliva secreted immunoglobulin A（sIgA） content and the Saccharomyces albicans adherency change rates.Methods To exam saliva sIgA content, to observe the Saccharomyces albicans standard and clinical separation in content of sIgA that is not contained in the sIgA environment and the buccal mucosa epithelial cell adherency rate by the sticky experiment, and to compare the differences of oral cavity Saccharomyces albicans adherency rate between HIV/acquired immunodeficiency syndrome（AIDS） group and healthy control group. Results ThesIgA content in HIV/AIDS group is lower than that of the healthy group（P＜0.05）. In the environment of sIgAcontent, the ensemble average of Saccharomyces albicans stick rate（standard and clinical separation） is lower than that of the non-sIgA environment, and therefore the differences between th