Hepatocellular carcinoma 2012——知识讲义.PDFVIP

Seminar Hepatocellular carcinoma Alejandro Forner, Josep M Llovet, Jordi Bruix Hepatocellular carcinoma is the sixth most prevalent cancer and the third most frequent cause of cancer-related Published Online death. Patients with cirrhosis are at highest risk of developing this malignant disease, and ultrasonography every February 20, 2012 6 months is recommended. Surveillance with ultrasonography allows diagnosis at early stages when the tumour DOI:10.1016/S0140- 6736(11)61347-0 might be curable by resection, liver transplantation, or ablation, and 5-year survival higher than 50% can be achieved. Barcelona Clinic Liver Cancer Patients with small solitary tumours and very well preserved liver function are the best candidates for surgical group, Liver Unit, Hospital resection. Liver transplantation is most benefi cial for individuals who are not good candidates for resection, especially Clínic Barcelona, August Pi those within Milano criteria (solitary tumour ≤5 cm and up to three nodules ≤3 cm). Donor shortage greatly limits its i Sunyer Biomedical Research applicability. Percutaneous ablation is the most frequently used treatment but its eff ectiveness is limited by tumour