人波形蛋白中间丝的结构与功能及其与肿瘤的关系_李祖茂.pdfVIP

2009 9 15 17 M e icalR ecapitulate, Sep 2009, V o.l 15, No. 17 2593 李祖茂 (, 637000) : R730. 2 : A : 1006-2084 ( 2009) 17-2593-03 : 波形蛋白是一种重要的型中间丝蛋白, 主要表达于胚胎组织和由间叶组织来源的成体 1B2A2B) - 细胞, 究表明波形蛋白在胚胎发育和细胞分化细胞的黏附和移动细胞凋亡炎症和免疫反应中 7 1 发挥重要的生物学功能然而, 到目前为止, 波形蛋白的确切功能仍然存在争议, 主要是因为波形蛋 4 白基因剔除小鼠没有出现异常的生物学表型癌细胞表达波形蛋白与其生长侵袭和肿瘤发生密切 相关, 波形蛋白与恶性肿瘤相互关系的 究已成为肿瘤分子生物学和肿瘤演进的一 个重要领域 7, : 波形蛋白; 生物学功能; 肿瘤 , Human V im entin Interm ediate F ilam ent: Structure, Function and Its A ssociation w ith Tum or LI - Z u-m ao. (D epa rtm en t of Pa th ology, N orth S ichuan M ed ical C ollege, N anchong 637000, Ch ina ) Abstract: V mi entin is a class III interm e iate filam ent prote in pre om inantly expresse in eveloping embryo an in cells ofm esenchym al origin in the a ult, is show n to play an mi portant ro le in v italm echanical ( an biolog ica l functions such as embryo evelopment an ifferentiation, cell attachm ent an m igration, apop- ) () tosis, inflamm ation an mi m unolog ical reaction. Still, until recently, the real tasks of vmi entin have been con- troversial, prmi arily because the v mi entin knockoutm ice w ere originally characterize as having a very m il 3 E 1 phenotype. V mi entin is expresse frequently in epithelial carcinom as associate w ith tum or grow th, invasive- ness an tum origenesis. The research about correlation betw een vmi entin an cancer is an mi portant fiel in () E2 (): biology an evolution of tum or. ; V 1() V 2 Key words: V mi entin; Biological function; Tum or (): ; H 1()H 2(): , 3 [ 2, 3]