述综丝裂原活化蛋白激酶信号通路和子宫内膜异位症.pdfVIP

112 国际生殖健康/ 计划生育杂志2010 年 3 月第 29 卷第 2 期 J Int Reprod Health Fam Plan ，March 2010 熏 Vol. 29熏 No. 2 综述 裂原活化蛋白激酶信号通路与子宫内膜异位症 马耀梅综述 王英红审校 【摘 要】 子宫内膜异位症是育龄妇女常见病。异位内膜的侵袭性种植是一个多因素参与的复杂 过程，涉及多条信号转导通路，其中丝裂原活化蛋白激酶（MAPK ）信号通路起了非常重要的作用。异位内 膜细胞在局部生长存活并随激素变化发生出血、炎症、免疫等反应。MAPK 通路在促异位内膜间质细胞增 殖，促炎症因子生成和促血管生成方面均起到显著作用。同时MAPK 通路诱导辅助性T（Th ）细胞发生 Th1/Th2 漂移，使异位内膜细胞发生免疫逃逸继而种植生长。 【关键词】 子宫内膜异位症；丝裂原活化蛋白激酶；信号转导通路 Mitogen Activated Protein Kinases Signaling Pathway and Endometriosis MA Y ao鄄mei, WA NG Y ing鄄hong. Medical Sc hool of Shihezi Unive rs ity, Xinj iang 832000, China Corres ponding author: W A NG Y ing鄄hong Email: wyhxj @yahoo. com. cn 【Abstract 】 Endometriosis is a common disease of women of reproductive age. The invasive implantation of ectopic endometrium is a complicated procedure, which involves in multiple factors and a few signaling pathways and mitogen activated protein kinase （MAPK ）signaling pathway plays the important role. Ectopic endometrium implants and grows on the surface of pelvic organs and followed with bleeding, inflammation and immunifaction and the reaction is steroid鄄dependent. MAPK signaling pathway makes a difference on stimulating endometriotic stromal cell proliferation, stimulating production of inflammatory factor and neovascularization. Also, it makes T helper （Th ）cells drift from Th1 to Th2, and makes the ectopic endometrium implant and grow through immune escaping. 【Key words 】 Endometriosis ；Mitogen activated protein kinases（MAPKs）；Signal pathway 渊 陨灶贼 砸藻责 则燥凿 匀藻葬造贼澡蛐云葬皂 孕造葬灶 袁2010 ，29 ：112-115冤 子宫内膜异位症（endometriosis, EMs ）是育龄妇 激酶（extracellular signal鄄regulated kinase ，ERK ）的活 女的常见病和多发病，发病率在 10% ～20% ，造成育 化，抑制了异位组织间质细胞的增殖。本文将对 龄妇女的不孕和慢性疼痛。研究EMs 发病机制证据 MAPK 信号通路与EMs 关系