孟鲁司特对咳嗽变异性哮喘患儿支气管肺泡灌洗液中嗜酸性粒细胞计数调节作用.pdfVIP

孟鲁司特对咳嗽变异性哮喘患儿支气管肺泡灌洗液中的嗜酸性粒细胞 计数的调节作用 孙杰1 2 1 1 1 ，王颖硕 ，徐震 ，施弦 ，王家蔚 (1.湖州市中心医院，浙江 湖州 313000 ；2.浙江大学医学院附属儿童医院，杭州 310003) 摘要：目的 探讨孟鲁司特对咳嗽变异性哮喘(cough variant asthma ，CVA) 患儿支气管肺泡灌洗液(BALF) 中的嗜酸性粒细 胞(EOS)计数的调节作用。方法 选择湖州市中心医院门诊及住院的CVA 患儿81 例，分成随机分为对照组(n=37)和治疗 组(n=44) 。对照组给予常规治疗，治疗组在常规治疗基础上加口服孟鲁司特钠咀嚼片5 mg ，每日1 次，治疗12 周。比较 2 组治疗前后肺功能与 BALF-EOS 比例变化。结果 治疗前对照组和治疗组 EOS 比例分别为(4.65±0.76)% 和 (4.51±0.67)% ，2 组比较差异无统计学意义(P0.05) ；治疗后对照组和治疗组 EOS 比例分别为(3.04±0.58)%和(1.93±0.51)% ， 2 组比较差异有统计学意义(P0.01) 。结论 孟鲁司特钠可以明显降低CVA 患儿BALF-EOS 水平。 关键词：孟鲁司特；咳嗽变异性哮喘；支气管肺泡灌洗液；嗜酸性粒细胞 中图分类号：R974+.3 文献标志码： 文章编号：1007-7693(2013)04-0434-03 Changes of Eosinophils in Bronchoalveolar Lavage Fluid of Cough Variant Asthma Children and Modulation Effect of Montelukast 1 2 1 1 1 SUN Jie , WANG Yingshuo , XU Zhen , SHI Xian , WANG Jiawei (1.Huzhou Central Hospital, Huzhou 313000, China; 2.The Children Hospital, Zhejiang University, School of Medicine, Hangzhou 310003, China) ABSTRACT: OBJECTIVE To observe the changes of eosinophils(EOS) in bronchoalveolar lavage fluid of cough variant asthma children before and after montelukast treatment. METHODS Eighty-one cough variant asthma children were randomly divided into treatment group(n=37) and control group(n=44). The control group was treated with conventional therapy, and the treatment group was given montelukast besides the conventional therapy. The level of EOS were observed before and after 12 weeks therapy between the two groups. RESULTS The level of EOS before therapy was (4.65±0.76)% and (4.51±0.67)% in control group and treatment group, respectively. There was no significant difference between the two groups(P0.05). The level of EOS after therapy was (3.04±0.58)% and (1.93±0.51)% in control g