汉族女性精神分裂症首发患者利培酮治疗所致闭经的危险因素.pdfVIP

ShanghaiArchivesofPsychiatr~2013，Vo1．25，No．1 · 45 · groups．Furtherstudy with largersampleswould be usetocliniciansinselectingantipsychoticmedicationsfor needed toassessthe interactioneffectsofestradiol， femalepatientswithschizophrenia：patientsathighest progesterone，prolactin and the otherhormonesin riskofdevelopingamenorrheaWOUIdbepreferentially the onset and persistence of medication—induced treatedwiththemedicationsthatareatIowestriskof amenorrhea． inducingamenorrhea．Alternatively,patientsathighest riskofdevelopingamenorrheacouldbeconcurrently 4．2 Limitations treatedwithagentssuchasmetforminthathavebeen shown to decrease the risk of medication-induced Thereareseveralfactorsthatneedtobeconsidered amenorrhea． when assessing these results．a1In choosing a first- Further work is needed to clarify the complex onset，drugnaivesampleweavoidedthecomplication relationships between antipsychotic medications， ofprioruseofantipsychoticmedication，butwefound reproductive hormones， protective agents and amuchIowerprevalenceofamenorrheathanreported amenorrhea；butthiscurrentstudyispartofagrowing inotherstudies(onIy6．3％after12weeksoftreatment) corpus of work that is gradually helping clinicians soitispossiblethatthe31subjectswithamenorrhea