原发性肝癌患者肝动脉化疗栓塞术前后血清TNFα与TGFβ1浓度变化及意义探讨.pdfVIP

● ● 2009 1 2 14 论著 （ ， 214005 ） α α 摘要: 目的 观察原发性肝癌患者肝动脉化疗栓塞术（TACE ）前后血清肿瘤坏死因子 （TNF ）、转 化生长因子β1 （TGF β1 ）的浓度变化。方法 随机选择30例确诊的原发性肝癌患者，用酶联免疫吸附试 验法检测患者术前和术后两周血清肿瘤坏死因子α （TNF α）、转化生长因子β1 （TGF β1 ）的浓度变 化。结果 治疗后两周患者肿瘤坏死因子α （TNF α）、转化生长因子β1 （TGF β1 ）的浓度变化明显下 P 降，与治疗前比较，差异有显著统计学意义（ 0.01 ）。结论 血清肿瘤坏死因子、转化生长因子的 浓度对TACE治疗原发性肝癌的预后观察具有一定的临床实用价值。 α β 关键词：原发性肝癌；肝动脉化疗栓塞；肿瘤坏死因子 ；转化生长因子 1 Observation of TNF α and TGF β changes in serum of patients with primary hepatic cancer before and 1 after transcatheter arterial chemoembolization and its clinical signicance LU Zhong-hua, DENG Jun, YANG Xiao-juan, PEI Hao, ZHUANG Lin-ni, CHEN Wei ( Wuxi Hospital for Infectious Diseases, Wuxi 214005, China) Abstract: Objective To observe the density changes of tumor necrosis factor α (TNF α) and transformation growth factor β (TGF β) in serum of patients with primary hepatic cancer before and after the treatment 1 1 of transcatheter hepatic arterial chemoembolization (TACE). Methods Thirty cases indentied as primary hepatic cancer were randomly selected and the density changes of TNF α and TGF β1 by enzyme linked immunosorbent assay (ELISA) before and after two weeks’ treatment were detected. Results The density change of patients’ TNF α and