2010肝动脉药物灌注加化疗栓塞治疗胆囊癌肝转移疗效评价.pdfVIP

当代医学 2010年4月第16卷第11期总第202期 Contemporary Medicine, Apr. 2010,Vol.16 No.11 Issue No.202 doi:10.3969/j.issn.1009-4393.2010.11.016 肝动脉药物灌注加化疗栓塞治疗胆囊癌肝转移疗效评价 宗登伟 郭晨阳 黎海亮 程洪涛 胡洪涛 肖金成 [摘要] 目的 评价肝动脉药物灌注加化疗栓塞治疗胆囊癌肝转移患者临床价值。方法 30例胆囊癌肝转移患者均采用肝动脉药物灌注加化疗 栓塞，共介入治疗110周期，化疗药物为吉西他滨+顺铂，栓塞剂采用超液化碘油。所有患者每次介入治疗前均行增强CT测量肿瘤大小，采用RECIST 标准评价疗效。采用Kaplan-Meier计算生存率。随访期限直至患者死亡。结果 本组患者完全缓解（CR）3%（1例），部分缓解（PR）50%（15 例），病变稳定（SD）20%（6例），病变进展（PD）27%（8例），总有效率（CR+PR）53%（16例）。1年生存率60%，2年生存率20%。介入治 疗始中位生存期13月，中位无进展生存期11月。结论 肝动脉药物灌注加化疗栓塞是治疗无法手术切除胆囊癌肝转移患者的有效方法。 [关键词] 肝转移瘤；胆囊癌；吉西他滨；介入治疗；疗效 Evaluation of efficacy of transarterial therapies of liver metastases from gallbladder cancer ZONG Deng-wei, GUO Chen-yang, LI Hai-liang*, CHENG Hong-tao, HU Hong-tao, XIAO Jin-cheng Department of Radiology, Henan anti-cancer Hospital, Zhengzhou, 457000 [Abstract] Objective To evaluate local tumor control and survival time after transarterial therapies in the palliative treatment of unresectable liver 入 介 瘤 肿 metastases in patients with gallbladder cancer. Methods A total of 30 patients with unresectable liver metastases of gallbladder cancer were repeatedly treated with transarterial therapies in 28-day intervals. A total of 110 transtarterial therapies procedures were performed (mean, 3.7 sessions per patient). The local chemotherapy protocol consisted of Gemcitabine and Cisplatin. Embolization was performed with lipiodol. Tumor response was evaluated with enhanced CT. The change in tumor size was calculated and the response was evaluated according to the Response Evaluation Criteria in Solid T Tum